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Abstract

Over the past decade, behavioral interventions have become increasingly recognized and recommended as effective first-line therapies for treating individuals with tic disorders. In this article, we describe a basic theoretical and conceptual framework through which the reader can understand the application of these interventions for treating tics. The three primary behavioral interventions for tics with the strongest empirical support (habit reversal, Comprehensive Behavioral Intervention for Tics, and exposure and response prevention) are described. Research on the efficacy and effectiveness of these treatments is summarized along with a discussion of the research evaluating the delivery of these treatments in different formats and modalities. The article closes with a review of the possible mechanisms of change underlying behavioral interventions for tics and areas for future research.

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2023-05-09
2024-04-28
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Literature Cited

  1. Albin RL, Mink JW. 2006. Recent advances in Tourette syndrome research. Trends Neurosci. 29:3175–82. https://doi.org/10.1016/j.tins.2006.01.001
    [Google Scholar]
  2. Am. Psychiatr. Assoc 2022. Diagnostic and Statistical Manual of Mental Disorders Washington, DC: Am. Psychiatr. Assoc. Publ., 5th ed.., text rev.
  3. Andrén P, Wachtmeister V, Franzé J, Speiner C, de la Cruz LF et al. 2021. Effectiveness of behaviour therapy for children and adolescents with Tourette syndrome and chronic tic disorder in a naturalistic setting. Child Psychiatry Hum. Dev. 52:4739–50. https://doi.org/10.1007/s10578-020-01098-y
    [Google Scholar]
  4. Azrin NH, Nunn RG. 1973. Habit-reversal: a method of eliminating nervous habits and tics. Behav. Res. Ther. 11:4619–28. https://doi.org/10.1016/0005-7967(73)90119-8
    [Google Scholar]
  5. Azrin NH, Nunn RG, Frantz SE. 1980. Habit reversal versus negative practice treatment of nervous tics. Behav. Ther. 11:2169–78. https://doi.org/10.1016/S0005-7894(80)80017-7
    [Google Scholar]
  6. Azrin NH, Peterson AL. 1990. Treatment of Tourette syndrome by habit reversal: a waiting-list control group comparison. Behav. Ther. 21:3305–18. https://doi.org/10.1016/s0005-7894(05)80333-8
    [Google Scholar]
  7. Banaschewski T, Woerner W, Rothenberger A. 2003. Premonitory sensory phenomena and suppressibility of tics in Tourette syndrome: developmental aspects in children and adolescents. Dev. Med. Child Neurol. 45:10700–3. https://doi.org/10.1111/j.1469-8749.2003.tb00873.x
    [Google Scholar]
  8. Barnea M, Benaroya-Milshtein N, Gilboa-Sechtman E, Woods DW, Piacentini J et al. 2016. Subjective versus objective measures of tic severity in Tourette syndrome: the influence of environment. Psychiatry Res. 242:204–9. https://doi.org/10.1016/j.psychres.2016.05.047
    [Google Scholar]
  9. Benito KG, Walther M. 2015. Therapeutic process during exposure: habituation model. J. Obsessive-Compuls. Relat. Disord. 6:147–57. https://doi.org/10.1016/j.jocrd.2015.01.006
    [Google Scholar]
  10. Black KJ, Kim S, Yang NY, Greene DJ. 2021. Course of tic disorders over the lifespan. Curr. Dev. Disord. Rep. 8:121–32. https://doi.org/10.1007/s40474-021-00231-3
    [Google Scholar]
  11. Bloch MH, Leckman JF. 2009. Clinical course of Tourette syndrome. J. Psychosom. Res. 67:6497–501. https://doi.org/10.1016/j.jpsychores.2009.09.002
    [Google Scholar]
  12. Blount TH, Raj JJ, Peterson AL. 2018. Intensive outpatient Comprehensive Behavioral Intervention for Tics: a clinical replication series. Cogn. Behav. Pract. 25:1156–67. https://doi.org/10.1016%2Fj.cbpra.2017.02.001
    [Google Scholar]
  13. Bohalter S, Goldfine A, Matteson S, Garraux G, Hanakawa T et al. 2006. Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study. Brain 129:82029–37. https://doi.org/10.1093/brain/awl050
    [Google Scholar]
  14. Brandt VC, Beck C, Sajin V, Baaske MK, Baumer T et al. 2016. Temporal relationship between premonitory urges and tics in Gilles de la Tourette syndrome. Cortex 77:24–37. http://dx.doi.org/10.1016/j.cortex.2016.01.008
    [Google Scholar]
  15. Bullen JG, Hemsley DR. 1983. Sensory experience as a trigger in Gilles de la Tourette's syndrome. J. Behav. Ther. Exp. Psychiatry 14:3197–201. https://doi.org/10.1016/0005-7916(83)90048-4
    [Google Scholar]
  16. Capriotti MR, Brandt BC, Ricketts EJ, Espil FM, Woods DW. 2012. Comparing the effects of differential reinforcement of other behavior and response-cost contingencies on tics in youth with Tourette syndrome. J. Appl. Behav. 45:2251–63. https://doi.org/10.1901/jaba.2012.45-251
    [Google Scholar]
  17. Capriotti MR, Brandt BC, Turkel JE, Lee J, Woods DW. 2014. Negative reinforcement and premonitory urges in youth with Tourette syndrome: an experimental evaluation. Behav. Modif. 38:2276–96. https://doi.org/10.1177/0145445514531015
    [Google Scholar]
  18. Capriotti MR, Piacentini JC, Himle MB, Ricketts EJ, Espil FM et al. 2015. Assessing environmental consequences of ticcing in youth with chronic tic disorders: the Tic Accommodation and Reactions Scale. Child. Health Care 44:3205–20. https://doi.org/10.1080/02739615.2014.948164
    [Google Scholar]
  19. Carr JE, Sidener TM, Sidener DW, Cummings AR. 2005. Functional analysis and habit-reversal treatment of tics. Behav. Interv. 20:3185–202. https://doi.org/10.1002/bin.193
    [Google Scholar]
  20. Carr JE, Taylor CC, Wallander RJ, Reiss ML. 1996. A functional-analytic approach to the diagnosis of a transient tic disorder. J. Behav. Ther. Exp. Psychiatry 27:3291–97. https://doi.org/10.1016/s0005-7916(96)00025-0
    [Google Scholar]
  21. Caurin B, Serrano M, Fernandez-Alvarez E, Campistol J, Perez-Duenas B. 2014. Environmental circumstances influencing tic expression in children. Eur. J. Paediatr. Neurol. 18:2157–62. https://doi.org/10.1016/j.ejpn.2013.10.002
    [Google Scholar]
  22. Chang S, Himle MB, Tucker BTP, Woods DW, Piacentini J. 2009. Initial psychometric properties of a brief parent-report instrument for assessing tic severity in children with chronic tic disorders. Child Fam. Behav. Ther. 31:3181–91. https://doi.org/10.1080/07317100903099100
    [Google Scholar]
  23. Chen CW, Wang HS, Chang HJ, Shueh CW. 2020. Effectiveness of a modified Comprehensive Behavioral Intervention for Tics for children and adolescents with Tourette's syndrome: a randomized controlled trial. J. Adv. Nurs. 76:3903–15. https://doi.org/10.1111/jan.14279
    [Google Scholar]
  24. Conelea CA, Woods DW. 2008. The influence of contextual factors on tic expression in Tourette syndrome: a review. J. Psychosom. Res. 65:5487–96. https://doi.org/10.1016/j.jpsychores.2008.04.010
    [Google Scholar]
  25. Conelea CA, Woods DW, Brandt BC. 2011a. The impact of a stress induction task on tic frequencies in youth with Tourette syndrome. Behav. Res. Ther. 49:8492–97. https://doi.org/10.1016/j.brat.2011.05.006
    [Google Scholar]
  26. Conelea CA, Woods DW, Zinner SH, Budman C, Murphy T et al. 2011b. Exploring the impact of Tourette syndrome on youth: results from the Tourette Syndrome Impact Survey. Child Psychiatry Hum. Dev. 42:2219–42. https://doi.org/10.1007/s10578-010-0211-4
    [Google Scholar]
  27. Conelea CA, Woods DW, Zinner SH, Budman CL, Murphy TK et al. 2013. The impact of Tourette syndrome in adults: results from the Tourette Syndrome Impact Survey. Commun. Ment. Health J. 49:1110–20. https://doi.org/10.1007/s10597-011-9465-y
    [Google Scholar]
  28. Cox JH, Seri S, Cavanna AE. 2016. Histaminergic modulation in Tourette syndrome. Expert Opin. Orphan Drugs 4:2205–13. https://doi.org/10.1517/21678707.2016.1128819
    [Google Scholar]
  29. Craske MG, Kircanski K, Zelikowsky M, Mystkowski J, Chowdhury N, Baker A. 2008. Optimizing inhibitory learning during exposure therapy. Behav. Res. Ther. 46:15–27. https://doi.org/10.1016/j.brat.2007.10.003
    [Google Scholar]
  30. Craske MG, Treanor M, Conway CC, Zbozinek T, Vervliet B. 2014. Maximizing exposure therapy: an inhibitory learning approach. Behav. Res. Ther. 58:10–23. http://doi.org/10.1016/j.brat.2014.04.006
    [Google Scholar]
  31. Crossley E, Seri S, Stern JS, Robertson MM, Cavanna AE. 2014. Premonitory urges for tics in adult patients with Tourette syndrome. Brain Dev. 36:145–50. https://doi.org/10.1016/j.braindev.2012.12.010
    [Google Scholar]
  32. Debes NMMM, Hjalgrim H, Skov L. 2009. The presence of comorbidity in Tourette syndrome increases the need for pharmacological treatment. J. Child Neurol. 24:121504–12. https://doi.org/10.1177/0883073808331363
    [Google Scholar]
  33. Deckersbach T, Chou T, Britton JC, Carlson LE, Reese HE et al. 2014. Neural correlates of behavior therapy for Tourette's disorder. Psychiatry Res. 224:3269–74. https://doi.org/10.1016/j.pscychresns.2014.09.003
    [Google Scholar]
  34. Deckersbach T, Rauch S, Buhlmann U, Wilhelm S 2006. Habit reversal versus supportive psychotherapy in Tourette's disorder: a randomized controlled trial and predictors of treatment response. Behav. Res. Ther. 44:81079–90. https://doi.org/10.1016/j.brat.2005.08.007
    [Google Scholar]
  35. Delorme C, Salvador A, Valabregue R, Roze E, Palminteri S et al. 2016. Enhanced habit formation in Gilles de la Tourette syndrome. Brain 139:2605–15. https://doi.org/10.1093/brain/awv307
    [Google Scholar]
  36. Dreison KC, Lagges AM. 2017. Effectiveness of the Comprehensive Behavioral Intervention for Tics (CBIT) in a pediatric psychiatry clinic: a retrospective chart review. Clin. Psychol. Pediatr. Psychol. 5:2180–85. https://doi.org/10.1037/cpp0000189
    [Google Scholar]
  37. Dufrene BA, Lestremau Harpole L, Sterling HE, Perry EJ, Burton B et al. 2013. Functional analysis identified habit reversal components for the treatment of motor tics. Child Fam. Behav. Ther. 35:141–62. https://doi.org/10.1080/07317107.2013.761036
    [Google Scholar]
  38. Eaton CK, Jones AM, Gutierrez-Colina AM, Ivey EK, Carlson O et al. 2017. The influence of environmental consequences and internalizing symptoms on children's tic severity. Child Psychiatry Hum. Dev. 48:2327–34. https://doi.org/10.1007/s10578-016-0644-5
    [Google Scholar]
  39. Elsner B, Jacobi T, Kischkel E, Schulze D, Reuter B. 2022. Mechanisms of exposure and response prevention in obsessive-compulsive disorder: effects of habituation and expectancy violation on short-term outcome in cognitive behavioral therapy. BMC Psychiatry 22:66 https://doi.org/10.1186/s12888-022-03701-z
    [Google Scholar]
  40. Espil FM, Woods DW, Specht MW, Bennett SM, Walkup JT et al. 2022. Long-term outcomes of behavior therapy for youth with Tourette disorder. J. Am. Acad. Child Adolesc. Psychiatry 61:6764–71. https://doi.org/10.1016/j.jaac.2021.08.022
    [Google Scholar]
  41. Essoe JK-Y, Ramsey KA, Singer HS, Grados M, McGuire JF. 2021a. Mechanisms underlying behavior therapy for Tourette's disorder. Curr. Dev. Disord. Rep. 8:3161–74. https://doi.org.10.1007/s40474-021-00225-1
    [Google Scholar]
  42. Essoe JK-Y, Ricketts EJ, Ramsey KA, Piacentini J, Woods DW et al. 2021b. Homework adherence predicts therapeutic improvement from behavior therapy in Tourette's disorder. Behav. Res. Ther. 140:103844 https://doi.org/10.1016/j.brat.2021.103844
    [Google Scholar]
  43. Evans J, Seri S, Cavanna AE. 2016. The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review. Eur. Child Adolesc. Psychiatry 25:9939–48. https://doi.org/10.1007/s00787-016-0823-8
    [Google Scholar]
  44. Evers RAF, van de Wetering BJM. 1994. A treatment model of motor tics based on a specific tension-reduction technique. J. Behav. Ther. Exp. Psychiatry 25:3255–60. https://doi.org/10.1016/0005-7916(94)90026-4
    [Google Scholar]
  45. Finis J, Enticott PG, Pollok B, Munchau A, Schnitzler A, Fitzgerald PB. 2013. Repetitive transcranial magnetic stimulation of the supplementary motor area induces echophenomena. Cortex 49:71978–82. https://doi.org/10.1016/j.cortex.2012.08.019
    [Google Scholar]
  46. Foa EB, McLean CP. 2016. The efficacy of exposure therapy for anxiety-related disorders and its underlying mechanisms: the case of OCD and PTSD. Annu. Rev. Clin. Psychol. 12:1–28. https://doi.org/10.1146/annurev-clinpsy-021815-093533
    [Google Scholar]
  47. Franklin ME, Best SH, Wilson MA, Loew B, Compton SN. 2011. Habit reversal training and acceptance and commitment therapy for Tourette syndrome: a pilot project. J. Dev. Phys. Disabil. 23:149–60. https://doi.org/10.1007/s10882-010-9221-1
    [Google Scholar]
  48. Freeman RD, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P. 2000. An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries. Dev. Med. Child Neurol. 42:7436–47. https://doi.org/10.1111/j.1469-8749.2000.tb00346.x
    [Google Scholar]
  49. Friedrich J, Spaleck H, Schappert R, Kleinmaker M, Verrel J et al. 2021. Somatosensory perception-action bindings in Tourette syndrome. Sci. Rep. 11:13388 https://doi.org/10.1038/s41598-021-92761-4
    [Google Scholar]
  50. Gagné JP. 2019. The psychology of Tourette disorder: revisiting the past and moving toward a cognitively oriented future. Clin. Psychol. Rev. 67:11–21. https://doi.org/10.1016/j.cpr.2018.09.005
    [Google Scholar]
  51. Ganos C, Garrido A, Navalpotro-Gomez I, Ricciardi L, Martino D et al. 2015. Premonitory urge to tic in Tourette's is associated with interoceptive awareness. Mov. Disord. 30:91198–202. https://doi.org/10.1002/mds.26228
    [Google Scholar]
  52. Ganos C, Ogrzal T, Schnitzler A, Munchau A. 2012. The pathophysiology of echopraxia/echolalia: relevance to Gilles de la Tourette syndrome. Mov. Disord. 27:101222–29. https://doi.org/10.1002/mds.25103
    [Google Scholar]
  53. Ganos C, Roessner V, Munchau A. 2013. The functional anatomy of Gilles de la Tourette syndrome. Neurosci. Biobehav. Rev. 37:61050–62. https://doi.org/10.1016/j.neubiorev.2012.11.004
    [Google Scholar]
  54. Godar SC, Bortolato M. 2017. What makes you tic? Translational approaches to study the role of stress and contextual triggers in Tourette syndrome. Neurosci. Biobehav. Rev. 76:123–33. http://dx.doi.org/10.1016/j.neubiorev.2016.10.003
    [Google Scholar]
  55. Goldman KJ, DeLeon IG. 2020. A review on functional analyses of tics. Behav. Modif. 44:2296–315. https://doi.org/10.1177/0145445518809046
    [Google Scholar]
  56. Grados MA, Riddle MA, Samuels JF, Liang KY, Hoehn-Saric R et al. 2001. The familial phenotype of obsessive-compulsive disorder in relations to tic disorders: the Hopkins OCD family study. Biol. Psychiatry 50:8559–65. https://doi.org/10.1016/s0006-3223(01)01074-5
    [Google Scholar]
  57. Guy W, Bonato R, eds. 1970. CGI: Clinical Global Impressions Chevy Chase, MD: Natl. Inst. Ment. Health
  58. Hebebrand J, Klug B, Fimmers R, Seuchter SA, Wettke-Schafer R et al. 1997. Rates for tic disorders and obsessive compulsive symptomology in families of children and adolescents with Gilles de la Tourette syndrome. J. Psychiatr. Res. 31:5519–30. https://doi.org/10.1016/s0022-3956(97)00028-9
    [Google Scholar]
  59. Heijerman-Holtgrefe AP, Verdellen CWJ, van de Griendt JMTM, Beljaars LPL, Kan KJ et al. 2021. Tackle your Tics: pilot findings of a brief, intensive group-based exposure therapy program for children with tic disorders. Eur. Child Adolesc. Psychiatry 30:3461–73. https://doi.org/10.1007/s00787-020-01532-5
    [Google Scholar]
  60. Himle MB, Capriotti MR, Hayes LP, Ramanujam K, Scahill L et al. 2014. Variables associated with tic exacerbation in children with chronic tic disorders. Behav. Modif. 38:2163–83. https://doi.org/10.1177/0145445514531016
    [Google Scholar]
  61. Himle MB, Chang S, Woods DW, Pearlman A, Buzzella B et al. 2006. Direct observation of tics in children with chronic tic disorders: reliability, validity, and feasibility. J. Appl. Behav. Anal. 39:429–40. https://doi.org/10.1901/jaba.2006.63-06
    [Google Scholar]
  62. Himle MB, Freitag M, Walther M, Franklin SA, Ely L, Woods DW 2012. A randomized pilot trial comparing videoconference versus face-to-face delivery of behavior therapy for childhood tic disorders. Behav. Res. Ther. 50:9565–70. https://doi.org/10.1016/j.brat.2012.05.009
    [Google Scholar]
  63. Himle MB, Woods DW. 2005. An experimental evaluation of tic suppression and the tic rebound effect. Behav. Res. Ther. 43:111443–51. https://doi.org/10.1016/j.brat.2004.11.002
    [Google Scholar]
  64. Himle MB, Woods DW, Bunaciu L. 2008. Evaluating the role of contingency in differentially reinforced tic suppression. J. Appl. Behav. Anal. 41:2285–89. https://doi.org/10.1901/jaba.2008.41-285
    [Google Scholar]
  65. Himle MB, Woods DW, Conelea CA, Bauer CC, Rice KA. 2007. Investigating the effects of tic suppression on premonitory urge ratings in children and adolescents with Tourette's syndrome. Behav. Res. Ther. 45:122964–76. https://doi.org/10.1016/j.brat.2007.08.007
    [Google Scholar]
  66. Hirschtritt ME, Lee PC, Pauls DL, Dion Y, Grados MA et al. 2015. Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome. JAMA Psychiatry 72:4325–33. https://doi.org/10.1001/jamapsychiatry.2014.2650
    [Google Scholar]
  67. Hoekstra P, Steenhuis MP, Troost PW, Korf J, Kallenberg CGM, Minderaa RB. 2004. Relative contribution of attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and tic severity to social and behavioral problems in tic disorders. J. Dev. Behav. Pediatr. 25:4272–79. https://doi.org/10.1097/00004703-200408000-00007
    [Google Scholar]
  68. Hollis C, Hall CL, Jones R, Marston L, Le Novere M et al. 2021. Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial. Lancet Psychiatry 8:10871–82. https://doi.org/10.1016/S2215-0366(21)00235-2
    [Google Scholar]
  69. Hoogduin K, Verdellen C, Cath D. 1997. Exposure and response prevention in the treatment of Gilles de la Tourette's syndrome: four case studies. Clin. Psychol. Psychother. 4:2125–35. https://doi.org/10.1002/(SICI)1099-0879(199706)4:2<125::AID-CPP125>3.0.CO;2-Z
    [Crossref] [Google Scholar]
  70. Houghton DC, Capriotti MR, Scahill LD, Wilhelm S, Peterson AL et al. 2017. Investigating habituation to premonitory urges in behavior therapy for tic disorders. Behav. Ther. 48:6834–46. https://doi.org/10.1016/j.beth.2017.08.004
    [Google Scholar]
  71. Hyde TM, Aaronson BA, Rickler RK, Weinberger DR. 1992. Relationship of birth weight to the phenotypic expression of Gilles de la Tourette's syndrome in monozygotic twins. Neurology 42:3652–58. https://doi.org/10.1212/WNL.42.3.652
    [Google Scholar]
  72. Izquierdo A, Brigman JL, Radke AK, Rudebeck PH, Holmes A. 2017. The neural basis of reversal learning: an updated perspective. Neuroscience 345:12–26. https://doi.org/10.1016/j.neuroscience.2016.03.021
    [Google Scholar]
  73. Jacoby RJ, Abramowitz JS. 2016. Inhibitory learning approaches to exposure therapy: a critical review and translation to obsessive-compulsive disorder. Clin. Psychol. Rev. 49:28–40. https://doi.org/10.1016/j.cpr.2016.07.001
    [Google Scholar]
  74. Kanaan AS, Gerasch S, Garcia-Garcia I, Lampe L, Pampel A et al. 2017. Pathological glutamatergic neurotransmission in Gilles de la Tourette syndrome. Brain 140:1218–34. https://doi.org/10.1093/brain/aww285
    [Google Scholar]
  75. Kennedy TM, Morris AT, Walkup JT, Barash M, Gettings JM et al. 2016. Rapid-response behavioral triage for tics (RRBTT): a 2-week clinical case series. Clin. Pract. Pediatr. Psychol. 4:4373–82. https://doi.org/10.1037/cpp0000151
    [Google Scholar]
  76. Kim S, Greene DJ, Bihun EC, Koller JM, Hampton JM et al. 2019. Provisional tic disorder is not so transient. Sci. Rep. 9:13951 https://doi.org/10.1038/s41598-019-40133-4
    [Google Scholar]
  77. Kleimaker A, Kleimaker M, Baumer T, Beste C, Munchau A. 2020. Gilles de la Tourette syndrome—a disorder of action-perception integration. Front. Neurol. 11:597898 https://doi.org/10.3389/fneur.2020.597898
    [Google Scholar]
  78. Knight T, Steeves T, Day L, Lowerison M, Jette N, Pringsheim T. 2012. Prevalence of tic disorders: a systematic review and meta-analysis. Pediatr. Neurol. 47:277–90. https://doi.org/10.1016/j.pediatrneurol.2012.05.002
    [Google Scholar]
  79. Koller WC, Biary NM. 1989. Volitional control of involuntary movements. Mov. Disord. 4:2153–56. https://doi.org/10.1002/mds.870040207
    [Google Scholar]
  80. Kurlan R, Lichter D, Hewitt D. 1989. Sensory tics in Tourette's syndrome. Neurology 39:5731–34. https://doi.org/10.1212/WNL.39.5.731
    [Google Scholar]
  81. Kwak C, Dat Vuong K, Jankovic J 2003. Premonitory sensory phenomenon in Tourette syndrome. Mov. Disord. 18:121530–33. https://doi.org/10.1002/mds.10618
    [Google Scholar]
  82. Lavoie ME, Leclerc J, O'Connor KP. 2013. Bridging neuroscience and clinical psychology: cognitive behavioral and psychophysiological models in the evaluation and treatment of Gilles de la Tourette syndrome. Neuropsychiatry 3:175–87
    [Google Scholar]
  83. Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL et al. 1989. The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J. Am. Acad. Child Adolesc. Psychiatry 28:4566–73. https://doi.org/10.1097/00004583-198907000-00015
    [Google Scholar]
  84. Leckman JF, Walker DE, Cohen DJ. 1993. Premonitory urges in Tourette syndrome. Am. J. Psychiatry 150:198–102. https://doi.org/10.1176/ajp.150.1.98
    [Google Scholar]
  85. Leckman JF, Zhang H, Vitale A, Lahnin F, Lynch K et al. 1998. Course of tic severity in Tourette syndrome: the first two decades. Pediatrics 102:114–19. https://doi.org/10.1542/peds.102.1.14
    [Google Scholar]
  86. Levy AM, Paschou P, Tumer Z. 2021. Candidate genes and pathways associated with Gilles de la Tourette syndrome—where are we?. Genes 12:91321 https://doi.org/10.3390/genes12091321
    [Google Scholar]
  87. Malatesta VJ. 1990. Behavioral case formulation: an experimental assessment study of transient tic disorder. J. Psychopathol. Behav. Assess. 12:3219–32. https://doi.org/10.1007/BF00960619
    [Google Scholar]
  88. Malli MA, Forrester-Jones R, Murphy G 2016. Stigma in youth with Tourette's syndrome: a systematic review and synthesis. Eur. J. Child Adolesc. Psychiatry 25:2127–39. https://doi.org/10.1007/s00787-015-0761-x
    [Google Scholar]
  89. Marchand E, Stice E, Rohde P, Becker CB. 2011. Moving from efficacy to effectiveness trials in prevention research. Behav. Res. Ther. 49:132–41. https://doi.org/10.1016/j.brat.2010.10.008
    [Google Scholar]
  90. Matsuda N, Nonaka M, Kono T, Fujio M, Nobuyoshi M, Kano Y. 2020. Premonitory awareness facilitates tic suppression: subscales of the Premonitory Urge for Tics Scale and a new self-report questionnaire for tic-associated sensations. Front. Psychiatry 11:592 https://doi.org/10.3389/fpsyt.2020.00592
    [Google Scholar]
  91. McGuire JF, Ricketts EJ, Scahill L, Wilhelm S, Woods DW et al. 2020. Effect of behavior therapy for Tourette's disorder on psychiatric symptoms and functioning in adults. Psychol. Med. 50:122046–56. https://doi.org/10.1017/s0033291719002150
    [Google Scholar]
  92. Miltenberger RG, Fuqua RW, Woods DW. 1998. Applying behavior analysis with clinical problems: review and analysis of habit reversal. J. Appl. Behav. Anal. 31:3447–69. https://doi.org/10.1901/jaba.1998.31-447
    [Google Scholar]
  93. Nelson AJD, Kantini E, Cassaday HJ 2013. An associative analysis of Tourette syndrome. Clinical Applications of Learning Theory M Haselgrove, L Hogarth 179–99. Hove, UK: Psychol. Press
    [Google Scholar]
  94. Nissen JB, Kaergaard M, Laursen L, Parner E, Thomsen PH. 2019a. Combined habit reversal training and exposure response prevention in a group setting compared to individual training: a randomized controlled clinical trial. Eur. Child Adolesc. Psychiatry 28:157–68. https://doi.org/10.1007/s00787-018-1187-z
    [Google Scholar]
  95. Nissen JB, Parner ET, Thomsen PH. 2019b. Predictors of therapeutic treatment outcome in adolescent chronic tic disorders. BJPsych Open 5:5E74 https://doi.org/10.1192/bjo.2019.56
    [Google Scholar]
  96. Nonaka M, Matsuda N, Kono T, Fujio M, Scahill L, Kano Y. 2015. Preliminary study of behavioral therapy for Tourette syndrome patients in Japan. Child. Health Care 44:3293–306. https://doi.org/10.1080/02739615.2014.979922
    [Google Scholar]
  97. O'Connor K. 2002. A cognitive-behavioral/psychophysiological model of tic disorder. Behav. Res. Ther. 40:101113–42. https://doi.org/10.1016/S0005-7967(02)00048-7
    [Google Scholar]
  98. O'Connor K, Brisebois H, Brault M, Robillard S, Loiselle J. 2003. Behavioral activity associated with onset in chronic tic and habit disorder. Behav. Res. Ther. 41:2241–49. https://doi.org/10.1016/S0005-7967(02)00051-7
    [Google Scholar]
  99. O'Connor K, Gareau D, Borgeat F. 1997. A comparison of a behavioural and a cognitive-behavioural approach to the management of chronic tic disorders. Clin. Psychol. Psychother. 4:2105–17. https://doi.org/10.1002/(sici)1099-0879(199706)4:2<105::aid-cpp126>3.0.co;2-y
    [Google Scholar]
  100. Openneer TJC, Tarnok Z, Bognar E, Benaroya-Milshtein N, Garcia-Delgar B et al. 2020. The Premonitory Urge for Tics Scale in a large sample of children and adolescents: psychometric properties in a developmental context. An EMTICS study. Eur. Child Adolesc. Psychiatry 29:101411–24. https://doi.org/10.1007/s00787-019-01450-1
    [Google Scholar]
  101. O'Rourke JA, Scharf JM, Yu D, Pauls DL 2009. The genetics of Tourette syndrome: a review. J. Psychosom. Res. 67:6533–45. https://doi.org/10.1016/j.jpsychores.2009.06.006
    [Google Scholar]
  102. Pagliaroli L, Veto B, Aranyi T, Barta C. 2016. From genetics to epigenetics: new perspectives in Tourette syndrome research. Front. Neurosci. 10:277 https://doi.org/10.3389/fnins.2016.00277
    [Google Scholar]
  103. Palminteri S, Lebreton M, Worbe Y, Hartmann A, Lehericy S et al. 2011. Dopamine-dependent reinforcement of motor skill learning: evidence from Gilles de la Tourette syndrome. Brain 134:82287–301. https://doi.org/10.1093/brain/awr147
    [Google Scholar]
  104. Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF. 1995. A family study of obsessive-compulsive disorder. Am. J. Psychiatry 152:176–84. https://doi.org/10.1176/ajp.152.1.76
    [Google Scholar]
  105. Pauls DL, Towbin KE, Leckman JF, Zahner GEP, Cohen DJ. 1986. Gilles de la Tourette's syndrome and obsessive-compulsive disorder: evidence supporting a genetic relationship. Arch. Gen. Psychiatry 43:121180–82. https://doi.org/10.1001/archpsyc.1986.01800120066013
    [Google Scholar]
  106. Perkins V, Coulson NS, Davies EB. 2020. Using online support communities for Tourette syndrome and tic disorders: online survey of users’ experiences. J. Med. Internet Res. 22:11e18099 https://doi.org/10.2196/18099
    [Google Scholar]
  107. Peterson BS, Skudlarski P, Anderson AW, Zhang H, Gatenby JC et al. 1998. A functional magnetic resonance imaging study of tic suppression in Tourette syndrome. Arch. Gen. Psychiatry 55:4326–33. https://doi.org/10.1001/archpsyc.55.4.326
    [Google Scholar]
  108. Petruo V, Bodmer B, Bluschke A, Munchau A, Roessner V, Beste C. 2020. Comprehensive Behavioral Intervention for Tics reduces perception-action binding during inhibitory control in Gilles de la Tourette syndrome. Sci. Rep. 10:11174 https://doi.org/10.1038/s41598-020-58269-z
    [Google Scholar]
  109. Petruo V, Bodmer B, Brandt VC, Baumung L, Roessner V et al. 2019. Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome. J. Child Psychol. Psychiatry 60:9953–62. https://doi.org/10.1111/jcpp.12938
    [Google Scholar]
  110. Piacentini J, Himle MB, Chang S, Baruch DE, Buzzella BA et al. 2006. Reactivity of tic observation procedures to situation and setting. J. Abnorm. Child Psychol. 34:5647–56. https://doi.org/10.1007/s10802-006-9048-5
    [Google Scholar]
  111. Piacentini J, Woods DW, Scahill L, Wilhelm S, Peterson AL et al. 2010. Behavior therapy for children with Tourette disorder: a randomized controlled trial. JAMA 303:191929–37. https://doi.org/10.1001/jama.2010.607
    [Google Scholar]
  112. Prato A, Maugeri N, Chiarotti F, Morcaldi L, Vicario CM et al. 2022. A randomized controlled trial comparing videoconference versus face-to-face delivery of behavior therapy for youths with Tourette syndrome in the time of COVID-19. Front. Psychiatry 13:862422 https://doi.org/10.3389/fpsyt.2022.862422
    [Google Scholar]
  113. Price RA, Kidd KK, Cohen DJ, Pauls DL, Leckman JF. 1985. A twin study of Tourette syndrome. Arch. Gen. Psychiatry 42:8815–20. http://doi.org/10.1001/archpsyc.1985.01790310077011
    [Google Scholar]
  114. Pringsheim T, Holler-Managan Y, Koun MS, Jankovic J, Piacentini J et al. 2019. Comprehensive systematic review summary: treatment of tics in people with Tourette syndrome and chronic tic disorders. Neurology 92:19907–15. https://doi.org/10.1212/WNL.0000000000007467
    [Google Scholar]
  115. Puts NAJ, Harris AD, Crocetti D, Nettles C, Singer MT et al. 2015. Reduced GABAergic inhibition and abnormal sensory symptoms in children with Tourette syndrome. J. Neurophysiol. 114:2808–17. https://doi.org/10.1152/jn.00060.2015
    [Google Scholar]
  116. Rachamim L, Zimmerman-Brenner S, Rachamim O, Mualem H, Zingboim N, Rotstein M. 2020. Internet-based guided self-help comprehensive behavioral intervention for tics (ICBIT) for youth with tic disorders: a feasibility and effectiveness study with 6 month-follow-up. Eur. Child Adolesc. Psychiatry 31:275–87. https://doi.org/10.1007/s00787-020-01686-2
    [Google Scholar]
  117. Rankin CH, Abrams T, Barry RJ, Bhatnagar S, Clayton DF et al. 2009. Habituation revisited: an updated and revised description of the behavioral characteristics of habituation. Neurobiol. Learn. Mem. 92:2135–38. https://doi.org/10.1016/j.nlm.2008.09.012
    [Google Scholar]
  118. Ricketts EJ, Goetz AR, Capriotti MR, Bauer CC, Brei NG et al. 2016. A randomized waitlist-controlled pilot trial of voice over Internet protocol-delivered behavior therapy for youth with chronic tic disorders. J. Telemed. Telecare 22:3153–62. https://doi.org/10.1177/1357633x15593192
    [Google Scholar]
  119. Rizzo R, Pellico A, Silvestri PR, Chiarotti F, Cardona F. 2018. A randomized controlled trial comparing behavioral, educational, and pharmacological treatments in youths with chronic tic disorder or Tourette syndrome. Front. Psychiatry 9:100 https://doi.org/10.3389/fpsyt.2018.00100
    [Google Scholar]
  120. Robertson MM. 2008. The prevalence and epidemiology of Gilles de la Tourette syndrome: part 1: the epidemiological and prevalence studies. J. Psychosom. Res. 65:5461–72. https://doi.org/10.1016/j.jpsychores.2008.03.006
    [Google Scholar]
  121. Rowe J, Yuen HK, Dure LS. 2013. Comprehensive behavioral intervention to improve occupational performance in children with Tourette disorder. Am. J. Occup. Ther. 67:2194–200. https://doi.org/10.5014/ajot.2013.007062
    [Google Scholar]
  122. Scahill L, Specht M, Page C. 2014. The prevalence of tic disorders and clinical characteristics in children. J. Obsessive-Compuls. Relat. Disord. 3:4394–400. http://dx.doi.org/10.1016/j.jocrd.2014.06.002
    [Google Scholar]
  123. Scholl C, Baladron J, Vitay J, Hamker FH. 2022. Enhanced habit formation in Tourette patients explained by shortcut modulation in a hierarchical cortico-basal ganglia model. Brain Struct. Funct. 227:31031–50. https://doi.org/10.1007/s00429-021-02446-x
    [Google Scholar]
  124. Scotti JR, Schulman DE, Hojnacki RM. 1994. Functional analysis and unsuccessful treatment of Tourette's syndrome in a man with profound mental retardation. Behav. Ther. 25:4721–38. https://doi.org/10.1016/S0005-7894(05)80206-0
    [Google Scholar]
  125. Silva RR, Munoz DM, Barickman J, Friedhoff AJ. 1995. Environmental factors and related fluctuation of symptoms in children and adolescents with Tourette's disorder. J. Child Psychol. Psychiatry 36:2305–12. https://doi.org/10.1111/j.1469-7610.1995.tb01826.x
    [Google Scholar]
  126. Singer HS. 2010. Treatment of tics and Tourette syndrome. Curr. Treat. Options Neurol. 12:6539–61. https://doi.org/10.1007/s11940-010-0095-4
    [Google Scholar]
  127. Singer HS, McDermott S, Ferenc L, Specht M, Mahone EM. 2020. Efficacy of parent-delivered, home-based therapy for tics. Pediatr. Neurol. 106:17–23. https://doi.org/10.1016/j.pediatrneurol.2019.12.015
    [Google Scholar]
  128. Specht MW, Woods DW, Nicotra CM, Kelly LM, Ricketts EJ et al. 2013. Effects of tic suppression: ability to suppress, rebound, negative reinforcement, and habituation to the premonitory urge. Behav. Res. Ther. 51:124–30. https://doi.org/10.1016/j.brat.2012.09.009
    [Google Scholar]
  129. Steeves T, McKinlay BD, Gorman D, Billinghurst L, Day L et al. 2012. Canadian guidelines for the evidence-based treatment of tic disorders: behavioural therapy, deep brain stimulation, and transcranial magnetic stimulation. Can. J. Psychiatry 57:3144–51. https://doi.org/10.1177/070674371205700303
    [Google Scholar]
  130. Stern E, Silbersweig DA, Chee K, Homles A, Robertson MM et al. 2000. A functional neuroanatomy of tics in Tourette syndrome. Arch. Gen. Psychiatry 57:8741–48. https://doi.org/10.1001/archpsyc.57.8.741
    [Google Scholar]
  131. Sukhodolsky DG, Woods DW, Piacentini J, Wilhelm S, Peterson AL et al. 2017. Moderators and predictors of response to behavior therapy for tics in Tourette's disorder. Neurology 88:111029–36. https://doi.org/10.1212/WNL.0000000000003710
    [Google Scholar]
  132. Tanner CM, Goetz CG, Klawans HL. 1982. Cholinergic mechanisms in Tourette syndrome. Neurology 32:111315–17. https://doi.org/10.1212/WNL.32.11.1315
    [Google Scholar]
  133. Tilling F, Cavanna AE. 2020. Relaxation therapy as a treatment for tics in patients with Tourette syndrome: a systematic literature review. Neurol. Sci. 41:51011–17. https://doi.org/10.1007/s10072-019-04207-5
    [Google Scholar]
  134. Tinaz S, Malone P, Hallett M, Horovitz SG. 2015. Role of the right dorsal anterior insula in the urge to tic in Tourette syndrome: a systematic review. Mov. Disord. 30:91190–97. https://doi.org/10.1002/mds.26230
    [Google Scholar]
  135. Verdellen CWJ, Hoogduin CAL, Kato BS, Keijsers GPJ, Cath DC, Hoijtink HB. 2008. Habituation of premonitory sensations during exposure and response prevention treatment in Tourette's syndrome. Behav. Modif. 32:2215–27. https://doi.org/10.1177/0145445507309020
    [Google Scholar]
  136. Verdellen CWJ, Keijsers GPJ, Cath DC, Hoogduin CAL. 2004. Exposure with response prevention versus habit reversal in Tourette's syndrome: a controlled study. Behav. Res. Ther. 42:5501–11. https://doi.org/10.1016/s0005-7967(03)00154-2
    [Google Scholar]
  137. Verdellen CWJ, van de Griendt J, Hartmann A, Murphy T. 2011a. European clinical guidelines for Tourette syndrome and other tic disorders. Part III: behavioural and psychosocial interventions. Eur. Child Adolesc. Psychiatry 20:4197–207. https://doi.org/10.1007/s00787-011-0167-3
    [Google Scholar]
  138. Verdellen CWJ, van de Griendt J, Kriens S, van Oostrum I. 2011b. Tics: Therapist Manual Amsterdam: Boom Publ.
  139. Viefhaus P, Feldhausen M, Gortz-Dorten A, Volk H, Dopfner M, Woitecki K. 2020. Efficacy of habit reversal training in children with chronic tic disorders: a within-subject analysis. Behav. Modif. 44:1114–36. https://doi.org/10.1177/0145445518796203
    [Google Scholar]
  140. Wang Z, Maia TV, Marsh R, Colibazzi T, Gerber A, Peterson BS. 2011. The neural circuits that generate tics in Tourette syndrome. Am. J. Psychiatry 168:121326–37. https://doi.org/10.1176/appi.ajp.2011.09111692
    [Google Scholar]
  141. Watson TS, Dufrene B, Weaver A, Butler T, Meeks C. 2005. Brief antecedent assessment and treatment of tics in a general education classroom: a preliminary investigation. Behav. Modif. 29:6839–57. https://doi.org/10.1177/0145445505279252
    [Google Scholar]
  142. Watson TS, Sterling HE. 1998. Brief functional analysis and treatment of a vocal tic. J. Appl. Behav. Anal. 31:3471–74. https://doi.org/10.1901/jaba.1998.31-471
    [Google Scholar]
  143. Wilhelm S, Deckersbach T, Coffey BJ, Bohne A, Peterson AL, Baer L. 2003. Habit reversal versus supportive psychotherapy for Tourette's disorder: a randomized controlled trial. Am. J. Psychiatry 160:61175–77. https://doi.org/10.1176/appi.ajp.160.6.1175
    [Google Scholar]
  144. Wilhelm S, Peterson AL, Piacentini JC, Woods DW, Deckersbach T et al. 2012. Randomized trial of behavior therapy for adults with Tourette's disorder. Arch. Gen. Psychiatry 69:8795–803. https://doi.org/10.1001/archgenpsychiatry.2011.1528
    [Google Scholar]
  145. Woods DW, Conelea CA, Himle MB. 2010. Behavior therapy for Tourette syndrome: an emerging area of practice for psychologists. Prof. Psychol. Res. Pract. 41:6518–25. https://doi.org/10.1037/a0021709
    [Google Scholar]
  146. Woods DW, Conelea CA, Walther MR. 2007. Barriers to dissemination: exploring the criticisms of behavior therapy for tics. Clin. Psychol. Sci. Pract. 14:3279–82. https://doi.org/10.1111/j.1468-2850.2007.00088.x
    [Google Scholar]
  147. Woods DW, Himle MB. 2004. Creating tic suppression: comparing the effects of verbal instruction to differential reinforcement. J. Appl. Behav. Anal. 37:3417–20. https://doi.org/10.1901/jaba.2004.37-417
    [Google Scholar]
  148. Woods DW, Himle MB, Miltenberger RG, Carr JE, Osmon DC et al. 2008a. Durability, negative impact, and neuropsychological predictors of tic suppression in children with chronic tic disorder. J. Abnorm. Child Psychol. 36:2237–45. https://doi.org/10.1007/s10802-007-9173-9
    [Google Scholar]
  149. Woods DW, Hook SS, Spellman DG, Friman PC. 2000. Case study: exposure and response prevention for an adolescent with Tourette's syndrome and OCD. J. Am. Acad. Child Adolesc. Psychiatry 39:7904–7. https://doi.org/10.1097/00004583-200007000-00020
    [Google Scholar]
  150. Woods DW, Miltenberger RG. 1996. A review of habit reversal with childhood habit disorders. Educ. Treat. Child. 19:2197–214
    [Google Scholar]
  151. Woods DW, Piacentini J, Chang S, Deckersbach T, Ginsburg G et al. 2008b. Managing Tourette Syndrome: A Behavioral Intervention for Children and Adults New York: Oxford Univ. Press
  152. Woods DW, Piacentini J, Himle MB, Chang S 2005. Premonitory Urge for Tics Scale: initial psychometric results and examination of the premonitory urge phenomenon in youths with tic disorders. J. Dev. Behav. Pediatr. 26:6397–403. https://doi.org/10.1097/00004703-200512000-00001
    [Google Scholar]
  153. Woods DW, Piacentini JC, Scahill LD, Peterson AL, Wilhelm S, Walkup JT 2011. Behavior Therapy for Tics in Children: acute and long term effects on secondary psychiatric and psychosocial functioning. J. Child Neurol. 26:7858–65. https://doi.org/10.1177/0883073810397046
    [Google Scholar]
  154. Woods DW, Walther MR, Bauer CC, Kemp JJ, Conelea CA. 2009. The development of stimulus control over tics: a potential explanation for contextually based variability in the symptoms of Tourette syndrome. Behav. Res. Ther. 47:141–47. https://doi.org/10.1016/j.brat.2008.10.013
    [Google Scholar]
  155. Woods DW, Watson TS, Wolfe E, Twohig MP, Friman PC. 2001. Analyzing the influence of tic-related talk on vocal and motor tics in children with Tourette's syndrome. J. Appl. Behav. Anal. 34:3353–56. https://doi.org/10.1901/jaba.2001.34-353
    [Google Scholar]
  156. Xu M, Kobets A, Du J, Lennington J, Li L et al. 2015. Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. PNAS 112:3893–98. https://doi.org/10.1073/pnas.1419533112
    [Google Scholar]
  157. Yang Z, Wu H, Lee PH, Tsetsos F, Davis LK et al. 2021. Investigating shared genetic basis across Tourette syndrome and comorbid neurodevelopmental disorders along the impulsivity-compulsivity spectrum. Biol. Psychiatry 90:5317–27. https://doi.org/j.biopsych.2020.12.028
    [Google Scholar]
  158. Yates R, Edwards K, King J, Luzon O, Evangeli M et al. 2016. Habit reversal training and educational group treatments for children with Tourette syndrome: a preliminary randomised controlled trial. Behav. Res. Ther. 80:43–50. https://doi.org/10.1016/j.brat.2016.03.003
    [Google Scholar]
  159. Yu D, Sul JH, Tsetsos F, Nawaz MS, Huang AY et al. 2019. Interrogating the genetic determinants of Tourette's syndrome and other tic disorders through genome-wide association studies. Am. J. Psychiatry 176:3217–27. https://doi.org/10.1176/appi.ajp.2018.18070857
    [Google Scholar]
  160. Zikis P. 1983. Treatment of an 11-year-old obsessive-compulsive ritualizer and tiqueur girl with in vivo exposure and response prevention. Behav. Cogn. Psychother. 11:175–81. https://doi.org/10.1017/S0141347300008831
    [Google Scholar]
  161. Zimmerman-Brenner S, Pilowsky-Peleg T, Rachamim L, Ben-Zvi A, Gur N et al. 2022. Group behavioral interventions for tics and comorbid symptoms in children with chronic tic disorders. Eur. Child Adolesc. Psychiatry 31:4637–48. https://doi.org/10.1007/s00787-020-01702-5
    [Google Scholar]
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