Mechanism and Regulation of Cytoplasmic Dynein: Supplemental Video 1

A video from the 2015 review by Michael A. Cianfrocco, Morgan E. DeSantis, Andres E. Leschziner, and Samara L. Reck-Peterson, "Mechanism and Regulation of Cytoplasmic Dynein," from the Annual Review of Cell and Developmental Biology.

Shown: Dynein’s mechanochemical cycle. This video shows an animated version of dynein’s mechanochemical cycle, as outlined in Figure 1d . The video illustrates a single step for a dynein head. In contrast to Figure 1d , here we include a full dimer. The color coding is the same as that used in Figure 1. We use steps to describe dynein’s mechanochemical cycle in the main text and to illustrate it in Figure 1d . We indicate those steps in this Supplemental Video so the reader can refer to the main text for a full description of the changes that take place.