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Abstract
Annual Review of Biomedical Engineering
Vol. 6: 185-208 (Volume publication date August 2004)
(doi:10.1146/annurev.bioeng.6.040803.140130)
MICRO-COMPUTED TOMOGRAPHY—CURRENT STATUS AND DEVELOPMENTS

Erik L. Ritman
Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905; email:

▪ Abstract The recent rapid increase in interest in tomographic imaging of small animals and of human (and large animal) organ biopsies is driven largely by drug discovery, cancer detection/monitoring, phenotype identification and/or characterization, and development of disease detection methods and monitoring efficacies of drugs in disease treatment. In biomedical applications, micro-computed tomography (CT) scanners can function as scaled-down (i.e., mini) clinical CT scanners that provide a three-dimensional (3-D) image of most, if not the entire, torso of a mouse at image resolution (50–100 μm) scaled proportional to that of a human CT image. Micro-CT scanners, on the other hand, image specimens the size of intact rodent organs at spatial resolutions from cellular (20 μm) down to subcellular dimensions (e.g., 1 μm) and fill the resolution-hiatus between microscope imaging, which resolves individual cells in thin sections of tissue, and mini-CT imaging of intact volumes.

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Author:
Erik L. Ritman
Keywords:
X-ray
synchrotron
contrast agents
three-dimensional
small animal

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