Abstract
Annual Review of Biomedical Engineering
Vol. 6:
185-208
(Volume publication date August 2004)
(doi:10.1146/annurev.bioeng.6.040803.140130)
MICRO-COMPUTED TOMOGRAPHY—CURRENT STATUS AND DEVELOPMENTS Erik L. RitmanDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905; email: elran@mayo.edu ▪ Abstract The recent rapid increase in interest in tomographic imaging of small animals and of human (and large animal) organ biopsies is driven largely by drug discovery, cancer detection/monitoring, phenotype identification and/or characterization, and development of disease detection methods and monitoring efficacies of drugs in disease treatment. In biomedical applications, micro-computed tomography (CT) scanners can function as scaled-down (i.e., mini) clinical CT scanners that provide a three-dimensional (3-D) image of most, if not the entire, torso of a mouse at image resolution (50–100 μm) scaled proportional to that of a human CT image. Micro-CT scanners, on the other hand, image specimens the size of intact rodent organs at spatial resolutions from cellular (20 μm) down to subcellular dimensions (e.g., 1 μm) and fill the resolution-hiatus between microscope imaging, which resolves individual cells in thin sections of tissue, and mini-CT imaging of intact volumes. Most recent citing papers (via CrossRef)Validation of Computed Tomographic Estimates of Intra-abdominal and Subcutaneous Adipose Tissue in Rats and Mice Micro-computed X-ray tomography: a new non-destructive method of assessing sectional, fly-through and 3D imaging of a soft-bodied marine worm Journal of Microscopy (2009) Hierarchical microimaging of bone structure and function Nature Reviews Rheumatology 5(7):373-381 (2009) Micro-computed tomography and alizarin red evaluations of boric acid-induced fetal skeletal changes in Sprague-Dawley rats Birth Defects Research Part B: Developmental and Reproductive Toxicology 86(3):214-219 (2009) Anticipating bipedalism: trabecular organization in the newborn ilium Journal of Anatomy 214(6):817-829 (2009)
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