Abstract
Annual Review of Neuroscience
Vol. 23:
155-184
(Volume publication date March 2000)
(doi:10.1146/annurev.neuro.23.1.155)
Emotion Circuits in the Brain Joseph E. LeDouxCenter for Neural Science, New York University, New York, New York, 10003; email: ledoux@cns.nyu.edu The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area. Much of the progress has come from studies of fear, and especially fear conditioning. This work has pinpointed the amygdala as an important component of the system involved in the acquisition, storage, and expression of fear memory and has elucidated in detail how stimuli enter, travel through, and exit the amygdala. Some progress has also been made in understanding the cellular and molecular mechanisms that underlie fear conditioning, and recent studies have also shown that the findings from experimental animals apply to the human brain. It is important to remember why this work on emotion succeeded where past efforts failed. It focused on a psychologically well-defined aspect of emotion, avoided vague and poorly defined concepts such as “affect,” “hedonic tone,” or “emotional feelings,” and used a simple and straightforward experimental approach. With so much research being done in this area today, it is important that the mistakes of the past not be made again. It is also time to expand from this foundation into broader aspects of mind and behavior Most recent citing papers (via CrossRef)Heightened Amygdala Long-Term Potentiation in Neurotensin Receptor Type-1 Knockout Mice Neuropsychopharmacology 33(13):3135-3145 (2009) Deficient maternal care resulting from immunological stress during pregnancy is associated with a sex-dependent enhancement of conditioned fear in the offspring Journal of Neurodevelopmental Disorders (2008) Functional Magnetic Resonance Imaging and Pediatric Anxiety Journal of the American Academy of Child & Adolescent Psychiatry 47(11):1217-1221 (2008) Impaired extinction of learned fear in rats selectively bred for high anxiety - evidence of altered neuronal processing in prefrontal-amygdala pathways European Journal of Neuroscience (2008) The serotonin transporter genotype is associated with intermediate brain phenotypes that depend on the context of eliciting stressor Molecular Psychiatry 13(11):1021-1027 (2008)
|
|
|
Users who read this review also read:
| Earl K. Miller, Jonathan D. Cohen Annual Review of Neuroscience. Volume 24, Page 167-202, Mar 2001 Abstract
| Full Text
| PDF (448 KB)
|
Add to Favorites
| Related | |
| J E LeDoux Annual Review of Psychology. Volume 46, Page 209-235, Jan 1995 First Page
| PDF (1801 KB)
|
Add to Favorites
| Related | |
| Elizabeth A. Phelps Annual Review of Psychology. Volume 57, Page 27-53, Jan 2006 Abstract
| Full Text
| PDF (247 KB)
|
Add to Favorites
| Related | |
| Stephen Maren Annual Review of Neuroscience. Volume 24, Page 897-931, Mar 2001 Abstract
| Full Text
| PDF (443 KB)
|
Add to Favorites
| Related | |
|
|