Abstract
Annual Review of Genetics
Vol. 31:
177-212
(Volume publication date December 1997)
(doi:10.1146/annurev.genet.31.1.177)
VIRAL TRANSACTIVATING PROTEINS Jane Flint1 and Thomas Shenk2Department of Molecular Biology 1, 2 and Howard Hughes Medical Institute 2, Princeton University, Princeton, New Jersey 08544–1014; e-mail: tshenk@princeton.edu ▪ Abstract Many viruses utilize the cellular transcription apparatus to express their genomes, and they encode transcriptional regulatory proteins that modulate the process. Here we review the current understanding of three viral regulatory proteins. The adenovirus E1A protein acts within the nucleus to regulate transcription through its ability to bind to other proteins. The herpes simplex type 1 virus VP16 protein acts within the nucleus to control transcription by binding to DNA in conjunction with cellular proteins. The human T-cell leukemia virus Tax protein influences transcription through interactions with cellular proteins in the nucleus as well as the cytoplasm. Most recent citing papers (via CrossRef)E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer K Fukuda, M Abei, H Ugai, R Kawashima, E Seo, M Wakayama, T Murata, S Endo, H Hamada, I Hyodo, K K Yokoyama Cancer Gene Therapy (2008) The cyclo‐oxygenase 2 promoter is induced in nontarget cells following adenovirus infection, but an AU‐rich 3′‐untranslated region destabilization element can increase specificity The Journal of Gene Medicine 10(7):744-753 (2008) Promyelocytic leukemia-nuclear body proteins: herpesvirus enemies, accomplices, or both? Future Virology 3(3):265-277 (2008) Systemic efficacy of oncolytic adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer International Journal of Cancer 121(1):165-174 (2007) Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism Wulf Schneider-Brachert, Vladimir Tchikov, Oliver Merkel, Marten Jakob, Cora Hallas, Marie-Luise Kruse, Peter Groitl, Alexander Lehn, Eberhard Hildt, Janka Held-Feindt, Thomas Dobner, Dieter Kabelitz, Martin Krönke, Stefan Schütze Journal of Clinical Investigation 116(11):2901-2913 (2006)
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