1932

Abstract

Pluripotency is a “blank” cellular state characteristic of specific cells within the early embryo (e.g., epiblast cells) and of certain cells propagated in vitro (e.g., embryonic stem cells, ESCs). The terms pluripotent cell and stem cell are often used interchangeably to describe cells capable of differentiating into multiple cell types. In this review, we discuss the prevailing molecular and functional definitions of pluripotency and the working parameters employed to describe this state, both in the context of cells residing within the early embryo and cells propagated in vitro.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-biochem-052709-104948
2012-07-07
2024-03-29
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-biochem-052709-104948
Loading
/content/journals/10.1146/annurev-biochem-052709-104948
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error