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Annual Review of Immunology

Volume 34, 2016

T Cell Fate at the Single-Cell Level

Abstract

T cell responses display two key characteristics. First, a small population of epitope-specific naive T cells expands by several orders of magnitude. Second, the T cells within this proliferating population take on diverse functional and phenotypic properties that determine their ability to exert effector functions and contribute to T cell memory. Recent technological advances in lineage tracing allow us for the first time to study these processes in vivo at single-cell resolution. Here, we summarize resulting data demonstrating that although epitope-specific T cell responses are reproducibly similar at the population level, expansion potential and diversification patterns of the offspring derived from individual T cells are highly variable during both primary and recall immune responses. In spite of this stochastic response variation, individual memory T cells can serve as adult stem cells that provide robust regeneration of an epitope-specific tissue through population averaging. We discuss the relevance of these findings for T cell memory formation and clinical immunotherapy.

Keyword(s): immunotherapy, robustness, stemness, stochasticity, T cell differentiation, T cell memory
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2016-05-20
2024-04-18
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T Cell Fate at the Single-Cell Level
Annual Review of Immunology 34, 65 (2016); https://doi.org/10.1146/annurev-immunol-032414-112014
/content/journals/10.1146/annurev-immunol-032414-112014
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