1932

Abstract

Each of us is a story. Mine is a story of doing science for 60 years, and I am honored to be asked to tell it. Even though this autobiography was written for the , I have chosen to describe my whole career in science because the segment that was immunology is so intertwined with all else I was doing. This article is an elongation and modification of a talk I gave at my 80th birthday celebration at Caltech on March 23, 2018.

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2019-04-26
2024-04-23
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Literature Cited

  1. 1.  Franklin RM, Baltimore D 1962. Patterns of macromolecular synthesis in normal and virus-infected mammalian cells. Cold Spring Harb. Symp. Quant. Biol. 27:175–98
    [Google Scholar]
  2. 2.  Baltimore D, Franklin R 1962. Preliminary data on a virus-specific enzyme system responsible for the synthesis of viral RNA. Biochem. Biophys. Res. Commun. 9:388–92
    [Google Scholar]
  3. 3.  Baltimore D, Franklin R 1963. Properties of the Mengovirus and poliovirus RNA polymerases. Cold Spring Harb. Symp. Quant. Biol. 28:105–8
    [Google Scholar]
  4. 4.  Baltimore D 1964. The Diversion of Macromolecular Synthesis in L-Cells Towards Ends Dictated by Mengovirus New York: Rockefeller Inst
  5. 5.  Baltimore D, Becker Y, Darnell JE 1964. Virus-specific double-stranded RNA in poliovirus-infected cells. Science 143:1034–36
    [Google Scholar]
  6. 6.  Darnell J, Penman S, Baltimore D 1965. Molecular events in the synthesis of poliovirus. Perspectives in Virology IV 16 M Pollard 16–33 New York: Harper Row
    [Google Scholar]
  7. 7.  Baltimore D, Girard M, Darnell J 1966. Aspects of the synthesis of poliovirus RNA and the formation of virus particles. Virology 29:179–89
    [Google Scholar]
  8. 8.  Maitra U, Novogrodsky A, Baltimore D, Hurwitz J 1965. The identification of nucleoside triphosphate ends on RNA formed in the RNA polymerase reaction. Biochem. Biophys. Res. Commun. 18:801–11
    [Google Scholar]
  9. 9.  Baltimore D, Girard M 1966. An intermediate in the synthesis of poliovirus RNA. PNAS 56:741–48
    [Google Scholar]
  10. 10.  Baltimore D, Huang AS 1970. Interaction of HeLa cell proteins with RNA. J. Mol. Biol. 47:263–73
    [Google Scholar]
  11. 11.  Huang AS, Baltimore D 1970. Initiation of polyribosome formation in poliovirus-infected HeLa cells. J. Mol. Biol. 47:275–91
    [Google Scholar]
  12. 12.  Jacobson MF, Baltimore D 1968. Polypeptide cleavages in the formation of poliovirus proteins. PNAS 61:77–84
    [Google Scholar]
  13. 13.  Baltimore D, Jacobson MF, Asso J, Huang AS 1969. The formation of poliovirus proteins. Cold Spring Harb. Symp. Quant. Biol. 34:741–46
    [Google Scholar]
  14. 14.  Stampfer M, Baltimore D, Huang AS 1969. Ribonucleic acid synthesis of vesicular stomatitis virus. I. Species of ribonucleic acid found in Chinese hamster ovary cells infected with plaque-forming and defective particles. J. Virology 4:154–61
    [Google Scholar]
  15. 15.  Baltimore D, Huang AS, Stampfer M 1970. Ribonucleic acid synthesis of vesicular stomatitis virus. II. An RNA polymerase in the virion. PNAS 66:572–76
    [Google Scholar]
  16. 16.  Baltimore D 1970. Viral RNA-dependent DNA polymerase. Nature 226:1209–11
    [Google Scholar]
  17. 17.  Temin HM, Mizutani S 1970. RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature 226:1211–13
    [Google Scholar]
  18. 18.  Baltimore D 1971. Expression of animal virus genomes. Bacteriol. Rev. 35:235–41
    [Google Scholar]
  19. 19.  Verma IM, Temple GF, Fan H, Baltimore D 1972. In vitro synthesis of DNA complementary to rabbit reticulocyte 10S RNA. Nat. New Biol. 235:163–67
    [Google Scholar]
  20. 20.  Gilboa E, Mitra SW, Goff S, Baltimore D 1979. A detailed model of reverse transcription and tests of crucial aspects. Cell 18:93–100
    [Google Scholar]
  21. 21.  Rosenberg N, Baltimore D, Scher CD 1975. In vitro transformation of lymphoid cells by Abelson murine leukemia virus. PNAS 72:1932–36
    [Google Scholar]
  22. 22.  Rosenberg N, Baltimore D 1976. A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J. Exp. Med. 143:1453–63
    [Google Scholar]
  23. 23.  Witte ON, Dasgupta A, Baltimore D 1980. Abelson murine leukemia virus protein is phosphorylated in vitro to form phosphotyrosine. Nature 283:826–31
    [Google Scholar]
  24. 24.  Druker BJ, Lydon NB 2000. Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J. Clin. Investig. 105:13–7
    [Google Scholar]
  25. 25.  Daley GQ, Van Etten RA, Baltimore D 1990. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 247:824–30
    [Google Scholar]
  26. 26.  Tonegawa S, Hozumi N 1976. Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. PNAS 73:103628–32
    [Google Scholar]
  27. 27.  Baltimore D 1974. Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes?. Nature 248:409–11
    [Google Scholar]
  28. 28.  Alt FW, Bothwell ALM, Knapp M, Siden E, Mather E et al. 1980. Synthesis of secreted and membrane-bound immunoglobulin μ heavy chains is directed by mRNAs that differ at their 3′-ends. Cell 20:293–301
    [Google Scholar]
  29. 29.  Alt FW, Enea V, Bothwell ALM, Baltimore D 1980. Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain. Cell 21:1–12
    [Google Scholar]
  30. 30.  Siden EJ, Baltimore D, Clark D, Rosenberg NE 1979. Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus. Cell 16:389–96
    [Google Scholar]
  31. 31.  Siden E, Alt FW, Shinefeld L, Sato V, Baltimore D 1981. Synthesis of immunoglobulin μ chain gene products precedes synthesis of light chains during B-lymphocyte development. PNAS 78:1823–27
    [Google Scholar]
  32. 32.  Alt F, Rosenberg N, Lewis S, Thomas E, Baltimore D 1981. Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: rearrangement of heavy but not light chain genes. Cell 27:381–90
    [Google Scholar]
  33. 33.  Lewis S, Rosenberg N, Alt F, Baltimore D 1982. Continuing kappa gene rearrangement in a cell line transformed by Abelson murine leukemia virus. Cell 30:807–16
    [Google Scholar]
  34. 34.  Schatz DG, Baltimore D 1988. Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts. Cell 53:107–15
    [Google Scholar]
  35. 35.  Schatz DG, Oettinger MA, Baltimore D 1989. The V(D)J recombination activating gene, RAG-1. Cell 59:1035–48
    [Google Scholar]
  36. 36.  Oettinger MA, Schatz DG, Gorka C, Baltimore D 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517–23
    [Google Scholar]
  37. 37.  Queen C, Baltimore D 1983. Immunoglobulin gene transcription is activated by downstream sequence elements. Cell 33:741–48
    [Google Scholar]
  38. 38.  Bergman Y, Rice D, Grosschedl R, Baltimore D 1984. Two regulatory elements for immunoglobulin κ light chain gene expression. PNAS 81:7041–45
    [Google Scholar]
  39. 39.  Singh H, Sen R, Baltimore D, Sharp PA 1986. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature 319:154–58
    [Google Scholar]
  40. 40.  Sen R, Baltimore D 1986. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705–16
    [Google Scholar]
  41. 41.  Staudt LM, Singh H, Sen R, Wirth T, Sharp PA, Baltimore D 1986. A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature 323:640–43
    [Google Scholar]
  42. 42.  Baltimore D 2011. NF-κB is 25. Nat. Immunol. 12:683–85
    [Google Scholar]
  43. 43.  Baeuerle PA, Baltimore D 1988. Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor. Cell 53:211–17
    [Google Scholar]
  44. 44.  Baeuerle PA, Baltimore D 1988. IκB: a specific inhibitor of the NF-κB transcription factor. Science 242:540–46
    [Google Scholar]
  45. 45.  Karin M, Staudt LM 2010. NF-κB: A Network Hub Controlling Immunity, Inflammation, and Cancer New York: Cold Spring Harb. Lab. Press
  46. 46.  Nabel G, Baltimore D 1987. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326:711–13
    [Google Scholar]
  47. 47.  Weaver D, Costantini F, Imanishi-Kari T, Baltimore D 1985. A transgenic immunoglobulin μ gene prevents rearrangement of endogenous genes. Cell 42:117–27
    [Google Scholar]
  48. 48.  Weaver D, Albanese C, Costantini F, Baltimore D 1991. Retraction: Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene. Cell 45:247–59
    [Google Scholar]
  49. 49.  Kevles D 1998. The Baltimore Case: A Trial of Politics, Science and Character New York: Norton
  50. 50.  Mayer BJ, Jackson PK, Van Etten RA, Baltimore D 1992. Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo. Mol. Cell. Biol. 12:609–18
    [Google Scholar]
  51. 51.  Ren R, Mayer BJ, Cichetti P, Baltimore D 1993. Identification of a ten-amino acid proline-rich SH3 binding site. Science 259:1157–61
    [Google Scholar]
  52. 52. Res. Integr. Adjudic. Panel. 1996. Thereza Imanishi-Kari, Ph.D DAB 1582, Jun 21 Dep. Health Hum. Serv
  53. 53.  Yang L, Qin X-F, Baltimore D, Van Parijs L 2002. Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells. PNAS 99:96204–9
    [Google Scholar]
  54. 54.  Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z et al. 2014. Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clin. Cancer Res. 20:92457–65
    [Google Scholar]
  55. 55.  Qin X-F, An DS, Chen ISY, Baltimore D 2002. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. PNAS 100:183–88
    [Google Scholar]
  56. 56.  Yang L, Yang H, Rideout K, Cho T, Joo KI et al. 2008. Engineered lentivector targeting of dendritic cells for in vivo immunization. Nat. Biotechnol. 26:326–34
    [Google Scholar]
  57. 57.  Pollack SM, Lu H, Gnjatic S, Somaiah N, O'Malley RB et al. 2017. First-in-human treatment with a dendritic cell-targeting lentiviral vector-expressing NY-ESO-1, LV305, induces deep, durable response in refractory metastatic synovial sarcoma patient. J. Immunol. 40:302–6
    [Google Scholar]
  58. 58.  Balazs AB, Chen J, Hong CM, Rao DS, Yang L, Baltimore D 2012. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature 481:81–84
    [Google Scholar]
  59. 59.  Deal C, Balazs AB, Espinosa DA, Zavala F, Baltimore D, Ketner G 2014. Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice. PNAS 111:12528–32
    [Google Scholar]
  60. 60.  Balazs AB, Bloom JD, Hong CM, Rao DS, Baltimore D 2013. Broad protection against influenza infection by vectored immunoprophylaxis in mice. Nat. Biotechnol. 31:647–52
    [Google Scholar]
  61. 61.  Taganov K, Boldin M, Chang KJ, Baltimore D 2006. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. PNAS 103:12481–86
    [Google Scholar]
  62. 62.  Hao S, Baltimore D 2013. RNA splicing regulates the temporal order of TNF-induced gene expression. PNAS 110:11934–39
    [Google Scholar]
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