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Annual Review of Nutrition

Volume 34, 2014

Bone Morphogenetic Proteins as Regulators of Iron Metabolism

Abstract

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGF-β) superfamily of signaling molecules. In addition to protean roles in embryonic development, germ-line specification, and cellular differentiation, a central role in iron homeostasis has recently been demonstrated for certain BMPs. Specifically, BMP6 serves to relate hepatic iron stores to the hepatocellular expression of the iron-regulatory hormone hepcidin. This regulation occurs via cellular SMAD-signaling molecules and is strongly modulated by the BMP coreceptor hemojuvelin (HJV). Mutations in certain genes influencing signaling to hepcidin via the BMP/SMAD pathway are associated with human disorders of iron metabolism, such as hereditary hemochromatosis and iron-refractory iron-deficiency anemia. Evidence suggests that signals in addition to iron stores influence hepcidin expression via the BMP/SMAD pathway. This review summarizes the details of BMP/SMAD signaling, with a particular focus on its role in iron homeostasis and iron-related diseases.

Keyword(s): bone morphogenic proteins, hepcidin, hereditary hemochromatosis, iron homeostasis
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2014-07-17
2024-04-19
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Bone Morphogenetic Proteins as Regulators of Iron Metabolism
Annual Review of Nutrition 34, 77 (2014); https://doi.org/10.1146/annurev-nutr-071813-105646
/content/journals/10.1146/annurev-nutr-071813-105646
/content/journals/10.1146/annurev-nutr-071813-105646
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