1932

Abstract

Recent worldwide emergence of multidrug-resistant and extensively drug-resistant tuberculosis is threatening to destabilize tuberculosis control programs and urging global attention to the development of alternative tuberculosis therapies. Major roadblocks limiting the development and effectiveness of new drugs to combat tuberculosis are the profound innate resistance of to host defense mechanisms as well as its intrinsic tolerance to chemotherapeutic reagents. The triangle of interactions among the pathogen, the host responses, and the drugs used to cure the disease are critical for the outcome of tuberculosis. We must better understand this three-way interaction in order to develop drugs that are able to kill the bacillus in the most effective way and minimize the emergence of drug resistance. Here we review our recent understanding of the molecular basis underlying intrinsic antibiotic resistance and survival tactics of . This knowledge may help to reveal current targets for the development of novel antituberculosis drugs.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-pharmtox-061008-103123
2009-02-10
2024-03-29
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-pharmtox-061008-103123
Loading
/content/journals/10.1146/annurev-pharmtox-061008-103123
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error