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Annual Review of Biochemistry

Volume 67, 1998

THE DNA REPLICATION FORK IN EUKARYOTIC CELLS

Abstract

Replication of the two template strands at eukaryotic cell DNA replication forks is a highly coordinated process that ensures accurate and efficient genome duplication. Biochemical studies, principally of plasmid DNAs containing the Simian Virus 40 origin of DNA replication, and yeast genetic studies have uncovered the fundamental mechanisms of replication fork progression. At least two different DNA polymerases, a single-stranded DNA-binding protein, a clamp-loading complex, and a polymerase clamp combine to replicate DNA. Okazaki fragment synthesis involves a DNA polymerase-switching mechanism, and maturation occurs by the recruitment of specific nucleases, a helicase, and a ligase. The process of DNA replication is also coupled to cell-cycle progression and to DNA repair to maintain genome integrity.

Keyword(s): cell cycle, Okazaki fragments, polymerase switching, replisome proteins, Simian virus 40
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1998-07-01
2024-04-19
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Literature Cited

  1. Diffley JFX. 1996. Genes Dev. 10:2819–30
  2. Stillman B. 1996. Science 274:1659–64
  3. Li JJ, Kelly TJ. 1984. Proc. Natl. Acad. Sci. USA 81:6973–77
  4. Li JJ, Kelly TJ. 1985. Mol. Cell. Biol. 5:1238–46
  5. Stillman BW, Gluzman Y. 1985. Mol. Cell. Biol. 5:2051–60
  6. Wobbe CR, Dean F, Weissbach L, Hurwitz J. 1985. Proc. Natl. Acad. Sci. USA 82:5710–14
  7. Challberg MD, Kelly TJ. 1989. Annu. Rev. Biochem. 58:671–717
  8. Stillman B. 1989. Annu. Rev. Cell. Biol. 5:197–245
  9. Bambara RA, Huang L. 1995. Prog. Nucleic Acid Res. Mol. Biol. 51:93–122
  10. Bambara RA, Murante RS, Henricksen LA. 1997. J. Biol. Chem. 272:4647–50
  11. Lindahl T, Barnes DE. 1992. Annu. Rev. Biochem. 61:251–81
  12. Nash R, Lindahl T. 1996. See Ref. 314 575–86
  13. Andersen AH, Bendixen C, Westergaard O. 1996. See Ref. 314 587–617
  14. Wang TS-F. 1996. See Ref. 314 461–93
  15. Nethanel T, Reisfeld S, Dinter-Gottlieb G, Kaufmann G. 1988. J. Virol. 6:2867–73
  16. Matsumoto T, Eki T, Hurwitz J. 1990. Proc. Natl. Acad. Sci. USA 87:9712–16
  17. Nethanel T, Kaufmann G. 1990. J. Virol. 64:5912–18
  18. Bullock PA, Seo YS, Hurwitz J. 1991. Mol. Cell. Biol. 11:2350–61
  19. Murakami Y, Eki T, Hurwitz J. 1992. Proc. Natl. Acad. Sci. USA 89:952–56
  20. Salas M, Miller JT, Leis J, DePamphilis ML. 1996. See Ref. 314 131–76
  21. Prelich G, Stillman B. 1988. Cell 53:117–26
  22. Lee S-H, Eki T, Hurwitz J. 1989. Proc. Natl. Acad. Sci. USA 86:7361–65
  23. Weinberg DH, Kelly TJ. 1989. Proc. Natl. Acad. Sci. USA 86:9742–46
  24. Tsurimoto T, Melendy T, Stillman B. 1990. Nature 346:534–39
  25. Tsurimoto T, Stillman B. 1991. J. Biol. Chem. 266:1961–68
  26. Waga S, Stillman B. 1994. Nature 369:207–12
  27. Murakami Y, Hurwitz J. 1993. J. Biol. Chem. 268:11008–17
  28. Wang TS-F. 1991. Annu. Rev. Biochem. 60:513–52
  29. Stadlbauer F, Brueckner A, Rehfuess C, Eckerskorn C, Lottspeich F. et al. 1994. Eur. J. Biochem. 222:781–93
  30. Brückner A, Stadlbauer F, Guarino LA, Brunahl A, Schneider C. et al. 1995. Mol. Cell. Biol. 15:1716–24
  31. Longhese MP, Jovine L, Plevani P, Lucchini G. 1993. Genetics 133:183–91
  32. Copeland WC, Tan X. 1995. J. Biol. Chem. 270:3905–13
  33. Longhese MP, Fraaschini R, Plevani P, Lucchini G. 1996. Mol. Cell. Biol. 16:3235–44
  34. Santocanale C, Foiani M, Lucchini G, Plevani P. 1993. J. Biol. Chem. 268:1343–48
  35. Bakkenist CJ, Cotterill S. 1994. J. Biol. Chem. 269:26759–66
  36. Collins KL, Russo AAR, Tseng BY, Kelly TJ. 1993. EMBO J. 12:4555–66
  37. Foiani M, Marini F, Gamba D, Lucchini G, Plevani P. 1994. Mol. Cell. Biol. 14:923–33
  38. Nasheuer H-P, Moore A, Wahl AF, Wang TS-F. 1991. J. Biol. Chem. 266:7893–903
  39. Foiani M, Liberi G, Lucchini G, Plevani P. 1995. Mol. Cell. Biol. 15:883–91
  40. Ferrari M, Lucchini G, Plevani P, Foiani M. 1996. J. Biol. Chem. 271:8661–66
  41. Voitenleitner C, Fanning E, Nasheuer H-P. 1997. Oncogene 14:1611–15
  42. Hübscher U, Maga G, Podust VN. 1996. See Ref. 314 525–43
  43. Wold MS. 1997. Annu. Rev. Biochem. 66:61–92
  44. Wobbe CR, Weissbach L, Borowiec JA, Dean FB, Murakami Y. et al. 1987. Proc. Natl. Acad. Sci. USA 84:1834–38
  45. Fairman MP, Stillman B. 1988. EMBO J. 7:1211–18
  46. Wold MS, Kelly T. 1988. Proc. Natl. Acad. Sci. USA 85:2523–27
  47. Sancar A. 1996. Annu. Rev. Biochem. 65:43–81
  48. Stahl H, Droge P, Knippers R. 1986. EMBO J. 5:1939–44
  49. Dean FB, Bullock P, Murakami Y, Wobbe CR, Weissbach L, Hurwitz J. 1987. Proc. Natl. Acad. Sci. USA 84:16–20
  50. Dodson M, Dean FB, Bullock P, Echols H, Hurwitz J. 1987. Science 238:964–67
  51. Wold MS, Li JJ, Kelly TJ. 1987. Proc. Natl. Acad. Sci. USA 84:3643–47
  52. Brill SJ, Stillman B. 1989. Nature 342:92–95
  53. Kenny MK, Lee S-H, Hurwitz J. 1989. Proc. Natl. Acad. Sci. USA 86:9757–61
  54. Tsurimoto T, Stillman B. 1989. EMBO J. 8:3883–89
  55. Erdile LF, Heyers W-D, Kolodner R, Kelly TJ. 1991. J. Biol. Chem. 266:12090–98
  56. Tsurimoto T, Stillman B. 1991. J. Biol. Chem. 266:1950–60
  57. Braun KA, Lao Y, He Z, Ingles CJ, Wold MS. 1997. Biochemistry 36:8443–54
  58. Longhese MP, Plevani P, Lucchini G. 1994. Mol. Cell. Biol. 14:7884–90
  59. Dornreiter I, Erdile LF, Gilbert IU, von Winkler D, Kelly TJ, Fanning E. 1992. EMBO J. 11:769–76
  60. Melendy T, Stillman B. 1993. J. Biol. Chem. 268:3389–95
  61. Ishiai M, Sanchez JP, Amin AA, Murakami Y, Hurwitz J. 1996. J. Biol. Chem. 271:20868–78
  62. Henricksen LA, Umbricht CB, Wold MS. 1994. J. Biol. Chem. 269:11121–32
  63. He Z, Wong JMS, Maniar HS, Brill SJ, Ingles CJ. 1996. J. Biol. Chem. 271:28243–49
  64. Stigger E, Dean FB, Hurwitz J, Lee S-H. 1994. Proc. Natl. Acad. Sci. USA 91:579–83
  65. Gomes XV, Wold MS. 1995. J. Biol. Chem. 270:4534–43
  66. Kim DK, Stigger E, Lee S-H. 1996. J. Biol. Chem. 271:15124–29
  67. Lin Y-L, Chen C, Keshav KF, Winchester E, Dutta A. 1996. J. Biol. Chem. 271:17190–98
  68. Philipova D, Mullen JR, Maniar HS, Lu JA, Gu CY, Brill SJ. 1996. Genes Dev. 10:2222–33
  69. Bochkarev A, Pfuetzner RA, Edwards AM, Frappier L. 1997. Nature 385:176–81
  70. Blackwell LJ, Borowiec JA. 1994. Mol. Cell. Biol. 14:3993–4001
  71. Kim C, Paulus BF, Wold MS. 1994. Biochemistry 33:14197–206
  72. Mitas M, Chock JY, Christy M. 1997. Biochem. J. 324:957–61
  73. Din S, Brill S, Fairman MP, Stillman B. 1990. Genes Dev. 4:968–77
  74. Liu VF, Weaver DT. 1993. Mol. Cell. Biol. 13:7222–31
  75. Carty MP, Zernik-Kobak M, McGrath S, Dixon K. 1994. EMBO J. 13:2114–23
  76. Dutta A, Stillman B. 1992. EMBO J. 11:2189–99
  77. Fotedar R, Roberts JM. 1992. EMBO J. 11:2177–87
  78. Brush GS, Anderson CW, Kelly TJ. 1994. Proc. Natl. Acad. Sci. USA 91:12520–24
  79. Pan Z-Q, Amin AA, Gibbs E, Niu H, Hurwitz J. 1994. Proc. Natl. Acad. Sci. USA 91:8343–47
  80. Boubnov NV, Weaver DT. 1995. Mol. Cell. Biol. 15:5700–6
  81. Fried LM, Koumenis C, Peterson SR, Green SL, van Zijl P. et al. 1996. Proc. Natl. Acad. Sci. USA 93:13825–30
  82. Gibbs E, Pan Z-Q, Niu H, Hurwitz J. 1996. J. Biol. Chem. 271:22847–54
  83. Niu H, Erdjument-Bromage H, Pan Z-Q, Lee S-H, Tempst P, Hurwitz J. 1997. J. Biol. Chem. 272:12634–41
  84. Zernik-Kobak M, Vasunia K, Connelly M, Anderson CW, Dixon K. 1997. J. Biol. Chem. 272:23896–904
  85. Brush GS, Morrow DM, Hieter P, Kelly TJ. 1996. Proc. Natl. Acad. Sci. USA 93:15075–80
  86. Cheng XB, Cheong N, Wang Y, Iliakis G. 1996. Radiother. Oncol. 39:43–52
  87. Abramova NA, Russell J, Botchan M, Li R. 1997. Proc. Natl. Acad. Sci. USA 94:7186–91
  88. Henricksen LA, Wold MS. 1994. J. Biol. Chem. 269:24203–8
  89. Pan Z-Q, Park CH, Amin AA, Hurwitz J, Sancar A. 1995. Proc. Natl. Acad. Sci. USA 92:4636–40
  90. Henricksen LA, Carter T, Dutta A, Wold MS. 1996. Nucleic Acids Res. 24:3107–12
  91. Morgan SE, Kastan MB. 1997. Cancer Res. 57:3386–89
  92. Adachi Y, Laemmli U. 1992. J. Cell Biol. 119:1–16
  93. Yan H, Newport J. 1995. Science 269:1883–85
  94. Coleman TR, Carpenter PB, Dunphy WG. 1996. Cell 87:53–63
  95. Stillman B. 1996. See Ref. 314 435–60
  96. Chen M, Pan Z-Q, Hurwitz J. 1992. Proc. Natl. Acad. Sci. USA 89:5211–15
  97. Chen M, Pan Z-Q, Hurwitz J. 1992. Proc. Natl. Acad. Sci. USA 89:2516–20
  98. Bunz F, Kobayashi R, Stillman B. 1993. Proc. Natl. Acad. Sci. USA 90:11014–18
  99. Burbelo PD, Utani A, Pan Z-Q, Yamada Y. 1993. Proc. Natl. Acad. Sci. USA 90:11543–47
  100. Howell EA, McAlear MA, Rose D, Holm C. 1994. Mol. Cell. Biol. 14:255–67
  101. Li XY, Burgers PMJ. 1994. Proc. Natl. Acad. Sci. USA 91:868–72
  102. Li XY, Burgers PMJ. 1994. J. Biol. Chem. 269:21880–84
  103. Noskov V, Maki S, Kawasaki Y, Leem S-H, Ono B-I. et al. 1994. Nucleic Acids Res. 22:1527–35
  104. Cullmann G, Fien K, Kobayashi R, Stillman B. 1995. Mol. Cell. Biol. 15:4661–71
  105. Bork P, Hofmann K, Bucher P, Neuwald AF, Altschul SF, Koonin EV. 1997. FASEB J. 11:68–76
  106. O'Donnell M, Onrust R, Dean FB, Chen M, Hurwitz J. 1993. Nucleic Acids Res. 21:1–3
  107. Tsurimoto T, Stillman B. 1989. Mol. Cell. Biol. 9:609–19
  108. Tsurimoto T, Stillman B. 1990. Proc. Natl. Acad. Sci. USA 87:1023–27
  109. Lee S-H, Kwong AD, Pan Z-Q, Hurwitz J. 1991. J. Biol. Chem. 266:594–602
  110. Yoder BL, Burgers PMJ. 1991. J. Biol. Chem. 266:22689–97
  111. Fien K, Stillman B. 1992. Mol. Cell. Biol. 12:155–63
  112. Podust VN, Georgaki A, Strack B, Hübscher U. 1992. Nucleic Acids Res. 20:4159–65
  113. Burgers PMJ. 1991. J. Biol. Chem. 266:22698–706
  114. Cai JS, Uhlmann F, Gibbs E, Flores-Rozas H, Lee C-G. et al. 1996. Proc. Natl. Acad. Sci. USA 93:12896–901
  115. Podust VN, Podust LM, Goubin F, Ducommun B, Hubscher U. 1995. Biochemistry 34:8869–75
  116. Lee S-H, Hurwitz J. 1990. Proc. Natl. Acad. Sci. USA 87:5672–76
  117. Podust VN, Fanning E. 1997. J. Biol. Chem. 272:6303–10
  118. Ellison V, Stillman B. 1998. J. Biol. Chem. 273:5979–87
  119. Gerik KJ, Gary SL, Burgers PMJ. 1997. J. Biol. Chem. 272:1256–62
  120. Fotedar R, Mossi R, Fitzgerald P, Rousselle T, Maga G. et al. 1996. EMBO J. 15:4423–33
  121. Mossi R, Jonsson Z, Allen BL, Hardin SH, Hubscher U. 1997. J. Biol. Chem. 272:1769–76
  122. Uhlmann F, Cai JS, Gibbs E, O'Donnell M, Hurwitz J. 1997. J. Biol. Chem. 272:10058–64
  123. Rheaume E, Cohen LY, Uhlmann F, Lazure C, Alam A. et al. 1997. EMBO J. 16:6346–54
  124. Song QZ, Lu H, Zhang N, Luckow B, Shah G. et al. 1997. Biochem. Biophys. Res. Commun. 233:343–48
  125. Uhlmann F, Gibbs E, Cai JS, O'Donnell M, Hurwitz J. 1997. J. Biol. Chem. 272:10065–71
  126. Uhlmann F, Cai JS, Flores-Rozas H, Dean FB, Finkelstein J. et al. 1996. Proc. Natl. Acad. Sci. USA 93:6521–26
  127. Cai JS, Gibbs E, Uhlmann F, Phillips B, Yao N. et al. 1997. J. Biol. Chem. 272:18974–81
  128. McAlear MA, Howell EA, Espenshade KK, Holm C. 1994. Mol. Cell. Biol. 14:4390–97
  129. Sugimoto K, Ando S, Shimomura T, Matsumoto K. 1997. Mol. Cell. Biol. 17:5905–14
  130. Guenther B, Onrust R, Sali A, O'Donnell M, Kuriyan J. 1997. Cell 91:335–45
  131. Jonsson ZO, Hübscher U. 1997. BioEssays 19:967–75
  132. Kelman Z. 1997. Oncogene 14:629–40
  133. Kong X-P, Onrust R, O'Donnell M, Kuriyan J. 1992. Cell 69:425–37
  134. Krishna TSR, Kong X-P, Gary S, Burgers PM, Kuriyan J. 1994. Cell 79:1233–43
  135. Kelman Z, O'Donnell M. 1995. Annu. Rev. Biochem. 64:171–200
  136. Tinker RL, Kassavetis GA, Geiduschek EP. 1994. EMBO J. 13:5330
  137. Hacker KJ, Alberts BM. 1994. J. Biol. Chem. 269:24209–20
  138. Hacker KJ, Alberts BM. 1994. J. Biol. Chem. 269:24221–28
  139. Stukenberg PT, Turner J, O'Donnell M. 1994. Cell 78:877–87
  140. Tan CK, Castillo C, So AG, Downey KM. 1986. J. Biol. Chem. 261:12310–16
  141. Bravo R, Frank R, Blundell PA, MacDonald-Bravo H. 1987. Nature 326:515–17
  142. Prelich G, Kostura M, Marshak DR, Mathews MB, Stillman B. 1987. Nature 326:471–75
  143. Prelich G, Tan CK, Kostura M, Mathews MB, So AG. et al. 1987. Nature 326:517–20
  144. Bauer GA, Burgers PMJ. 1988. Proc. Natl. Acad. Sci. USA 85:7506–10
  145. Hamatake RK, Hasegawa H, Clark AB, Bebenek K, Kunkel TA, Sugino A. 1990. J. Biol. Chem. 265:4072–83
  146. Lee S-H, Zhen-Qiang P, Kwong AD, Burgers PMJ, Hurwitz J. 1991. J. Biol. Chem. 266:22707–17
  147. Chui G, Linn S. 1995. J. Biol. Chem. 270:7799–808
  148. Ayyagari R, Impellizzeri KJ, Yoder BL, Gary SL, Burgers PMJ. 1995. Mol. Cell. Biol. 15:4420–29
  149. Fukuda K, Morioka H, Imajou S, Ikeda S, Ohtsuka E, Tsurimoto T. 1995. J. Biol. Chem. 270:22527–34
  150. Arroyo MP, Downey KM, So AG, Wang TS-F. 1996. J. Biol. Chem. 271:15971–80
  151. Eissenberg JC, Ayyagari R, Gomes XV, Burgers PM. 1997. Mol. Cell. Biol. 17:6367–78
  152. Li XY, Li J, Harrington J, Lieber MR, Burgers PMJ. 1995. J. Biol. Chem. 270:22109–12
  153. Chen JJ, Chen S, Saha P, Dutta A. 1996. Proc. Natl. Acad. Sci. USA 93:11597–602
  154. Levin DS, Bai W, Yao N, O'Donnell M, Tomkinson AE. 1997. Proc. Natl. Acad. Sci. USA 94:12863–68
  155. Flores-Rozas H, Kelman Z, Dean FB, Pan Z-Q, Harper JW. et al. 1994. Proc. Natl. Acad. Sci. USA 91:8655–59
  156. Waga S, Hannon GJ, Beach D, Stillman B. 1994. Nature 369:574–78
  157. Smith ML, Chen I-T, Zhan QM, Bae IS, Chen C-Y. et al. 1994. Science 266:1376–80
  158. Hall PA, Kearsey JM, Coates PJ, Norman DG, Warbrick E, Cox LS. 1995. Oncogene 10:2427–33
  159. Gary R, Ludwig DL, Cornelius HL, MacInnes MA, Park MS. 1997. J. Biol. Chem. 272:24522–29
  160. Chuang LS-H, Ian H-I, Koh T-W, Ng H-H, Xu GL, Li BFL. 1997. Science 277:1996–2000
  161. Umar A, Buermeyer AB, Simon JA, Thomas DC, Clark AB. et al. 1996. Cell 87:65–73
  162. Xiong Y, Zhang H, Beach D. 1992. Cell 71:505–14
  163. Matsuoka S, Yamaguchi M, Matsukage A. 1994. J. Biol. Chem. 269:11030–36
  164. Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J. 1996. Cell 87:297–306
  165. Roos G, Jiang Y, Landberg G, Nielsen NH, Zhang P, Lee MYWT. 1996. Exp. Cell Res. 226:208–13
  166. Bravo R, MacDonald-Bravo H. 1987. J. Cell Biol. 105:1549–54
  167. Humbert C, Santisteban MS, Usson Y, Robert-Nicoud M. 1992. J. Cell Sci. 103:97–103
  168. Li R, Hannon GJ, Beach D, Stillman B. 1996. Curr. Biol. 6:189–99
  169. Celis JE, Madsen P. 1986. FEBS Lett. 209:277–83
  170. Toschi L, Bravo R. 1988. J. Cell Biol. 107:1623–28
  171. Miura M, Domon M, Sasaki T, Kondo S, Takasaki Y. 1992. Exp. Cell Res. 201:541–44
  172. Pagano M, Theodoras AM, Tam SW, Draetta GF. 1994. Genes Dev. 8:1627–39
  173. Hughes DA, MacNeill SA, Fantes PA. 1992. Mol. Gen. Genet. 231:401–10
  174. MacNeill SA, Moreno S, Reynolds N, Nurse P, Fantes PA. 1996. EMBO J. 15:4613–28
  175. Zuo S, Gibbs E, Kelman Z, Wang TS-F, O'Donnell M. et al. 1997. Proc. Natl. Acad. Sci. USA 94:11244–49
  176. Boulet A, Simon M, Faye G, Bauer GA, Burgers PMJ. 1989. EMBO J. 8:1849–54
  177. Pignede G, Bouvier D, Recondo A-M, Baldacci G. 1991. J. Mol. Biol. 222:209–18
  178. Zhang J, Chung DW, Tan C-K, Downey KM, Davie EW, So AG. 1991. Biochemistry 30:11742–50
  179. Yang C-L, Chang L-S, Zhang P, Hao H, Zhu L. et al. 1992. Nucleic Acids Res. 20:735–45
  180. Cullmann G, Hindges R, Berchtold MW, Hübscher U. 1993. Gene 134:191–200
  181. Park H, Francesconi S, Wang TS-F. 1993. Mol. Biol. Cell 4:145–57
  182. Sugimoto K, Sakamoto Y, Takahashi O, Matsumoto K. 1995. Nucleic Acids Res. 23:3493–500
  183. Zhang J, Tan C-K, McMullen B, Downey KM, So AG. 1995. Genomics 29:179–86
  184. Zhou J-Q, He H, Tan C-K, Downey KM, So AG. 1997. Nucleic Acids Res. 25:1094–99
  185. Brown WC, Campbell JL. 1993. J. Biol. Chem. 268:21706–10
  186. Zhang S-J, Zeng X-R, Zhang P, Toomey NL, Chuang R-Y. et al. 1995. J. Biol. Chem. 270:7988–92
  187. Goulian M, Herrmann SM, Sackett JW, Grimm SL. 1990. J. Biol. Chem. 265:16402–11
  188. Chiang C-S, Mitsis PG, Lehman IR. 1993. Proc. Natl. Acad. Sci. USA 90:9105–9
  189. Melendy T, Stillman B. 1991. J. Biol. Chem. 266:1942–49
  190. Weinberg DH, Collins KL, Simancek P, Russo A, Old MS. et al. 1990. Proc. Natl. Acad. Sci. USA 87:8692–96
  191. Eki T, Matsumoto T, Murakami Y, Hurwitz J. 1992. J. Biol. Chem. 267:7284–94
  192. Waga S, Bauer G, Stillman B. 1994. J. Biol. Chem. 269:10923–34
  193. Maga G, Hübscher U. 1996. Biochemistry 35:5764–77
  194. McConnell M, Miller H, Mozzherin DJ, Quamina A, Tan C-K. et al. 1996. Biochemistry 35:8268–74
  195. Zlotkin T, Kaufmann G, Jiang Y, Lee MYWT, Uitto L. et al. 1996. EMBO J. 15:2298–305
  196. Morrison A, Araki H, Clark B, Hamatake RK, Sugino A. 1990. Cell 62:1143–51
  197. Araki H, Ropp PA, Johnson AL, Johnston LH, Morrison A, Sugino A. 1992. EMBO J. 11:733–40
  198. Budd ME, Campbell JL. 1993. Mol. Cell. Biol. 13:496–505
  199. Podust VN, Hübscher U. 1993. Nucleic Acids Res. 21:841–46
  200. Turchi JJ, Huang L, Murante RS, Kim Y, Bambara RA. 1994. Proc. Natl. Acad. Sci. USA 91:9803–7
  201. Lieber MR. 1997. BioEssays 19:233–40
  202. Harrington JJ, Lieber MR. 1994. Genes Dev. 8:1344–55
  203. Murray JM, Tavassoli M, Al-Harithy R, Sheldrick KS, Lehmann AR. et al. 1994. Mol. Cell. Biol. 14:4878–88
  204. Harrington JJ, Lieber MR. 1994. EMBO J. 13:1235–46
  205. Ishimi Y, Claude A, Bullock P, Hurwitz J. 1988. J. Biol. Chem. 263:19723–33
  206. Goulian M, Richards SH, Heard CJ, Bigsby BM. 1990. J. Biol. Chem. 265:18461–71
  207. Robins P, Pappin DJC, Wood RD, Lindahl T. 1994. J. Biol. Chem. 269:28535–38
  208. Siegel G, Turchi J, Myers T, Bambara R. 1992. Proc. Natl. Acad. Sci. USA 89:9377–81
  209. Kenny MK, Balogh LA, Hurwitz J. 1988. J. Biol. Chem. 263:9801–8
  210. Reagan MS, Pittenger C, Siede W, Friedberg EC. 1995. J. Bacteriol. 177:364–71
  211. Sommers CH, Miller EJ, Dujon B, Prakash S, Prakash L. 1995. J. Biol. Chem. 270:4193–96
  212. Turchi JJ, Bambara RA. 1993. J. Biol. Chem. 268:15136–41
  213. Murante RS, Huang L, Turchi JJ, Bambara RA. 1994. J. Biol. Chem. 269:1191–96
  214. Huang L, Rumbaugh JA, Murante RS, Lin RJR, Rust L, Bambara RA. 1996. Biochemistry 35:9266–77
  215. Murante RS, Rumbaugh JA, Barnes CJ, Norton JR, Bambara RA. 1996. J. Biol. Chem. 271:25888–97
  216. Murante RS, Rust L, Bambara RA. 1995. J. Biol. Chem. 270:30377–83
  217. Biswas EE, Zhu FZ, Biswas SB. 1997. Biochemistry 36:5955–62
  218. Johnson RE, Kovvali GK, Prakash L, Prakash S. 1995. Science 269:238–40
  219. Tishkoff DX, Filosi N, Gaida GM, Kolodner RD. 1997. Cell 88:253–63
  220. Gordenin DA, Kunkel TA, Resnick MA. 1997. Nat. Genet. 16:116–18
  221. Kunkel TA, Resnick MA, Gordenin DA. 1997. Cell 88:155–58
  222. Cathala G, Rech J, Huet J, Jeanteur P. 1979. J. Biol. Chem. 254:7353–61
  223. Büsen W. 1980. J. Biol. Chem. 255:9434–43
  224. DiFrancesco RA, Lehman IR. 1985. J. Biol. Chem. 260:14764–70
  225. Hagemeier A, Grosse F. 1989. Eur. J. Biochem. 185:621–28
  226. Eder PS, Walder JA. 1991. J. Biol. Chem. 266:6472–79
  227. Huang L, Kim Y, Turchi JJ, Bambara RA. 1994. J. Biol. Chem. 269:25922–27
  228. Rumbaugh JA, Murante RS, Shi S, Bambara RA. 1997. J. Biol. Chem. 272:22591–99
  229. Borowiec JA. 1996. See Ref. 314 545–74
  230. Wessel R, Schweizer J, Stahl H. 1992. J. Virol. 66:804–15
  231. Kuo C-L, Huang C-H, Campbell JL. 1983. Proc. Natl. Acad. Sci. USA 80:6465–69
  232. Budd ME, Campbell JL. 1995. Proc. Natl. Acad. Sci. USA 92:7642–46
  233. Budd ME, Choe W-C, Campbell JL. 1995. J. Biol. Chem. 270:26766–69
  234. Matsumoto K, Seki M, Masutani C, Tada S, Enomoto T, Ishimi Y. 1995. Biochemistry 34:7913–22
  235. Saitoh A, Tada S, Katada T, Enomoto T. 1995. Nucleic Acids Res. 23:2014–18
  236. Seki M, Kohda T, Yano T, Tada S, Yanagisawa J. et al. 1995. Mol. Cell. Biol. 15:165–72
  237. Chong JPJ, Thommes P, Blow JJ. 1996. Trends Biochem. Sci. 21:102–6
  238. Kearsey SE, Maiorano D, Holmes EC, Todorov IT. 1996. BioEssays 18:183–90
  239. Koonin EV. 1993. Nucleic Acids Res. 21:2541–47
  240. Adachi Y, Usukura J, Yanagida M. 1997. Genes Cells 2:467–79
  241. Aparicio OM, Weinstein DM, Bell SP. 1997. Cell 91:59–69
  242. Ishimi Y. 1997. J. Biol. Chem. 272:24508–13
  243. Tom TD, Malkas LH, Hickey RJ. 1996. J. Cell. Biochem. 63:259–67
  244. Budd ME, Campbell JL. 1997. Mol. Cell. Biol. 17:2136–42
  245. Wittmeyer J, Formosa T. 1997. Mol. Cell. Biol. 17:4178–90
  246. Kouprina N, Kroll E, Bannikov V, Bliskovsky V, Gizatullin R. et al. 1992. Mol. Cell. Biol. 12:5736–47
  247. Miles J, Formosa T. 1992. Mol. Cell. Biol. 12:5724–35
  248. Miles J, Formosa T. 1992. Proc. Natl. Acad. Sci. USA 89:1276–80
  249. Prendergast JA, Murray LE, Rowley A, Carruthers DR, Singer RA, Johnston GC. 1990. Genetics 124:81–90
  250. Malone EA, Clark CD, Chiang A, Winston F. 1991. Mol. Cell. Biol. 11:5710–17
  251. Rowley A, Singer RA, Johnston GC. 1991. Mol. Cell. Biol. 11:5718–26
  252. Vallen EA, Cross FR. 1995. Mol. Cell. Biol. 15:4291–302
  253. Fanning E, Knippers R. 1992. Annu. Rev. Biochem. 61:55–85
  254. Deleted in proof
  255. Murakami Y, Hurwitz J. 1993. J. Biol. Chem. 268:11018–27
  256. Smale ST, Tjian R. 1986. Mol. Cell. Biol. 6:4077–87
  257. Gannon JV, Lane DP. 1987. Nature 329:456–58
  258. Dornreiter I, Höss A, Arthur AK, Fanning E. 1990. EMBO J. 9:3329–36
  259. Dornreiter I, Copeland WC, Wang TS-F. 1993. Mol. Cell. Biol. 13:809–20
  260. Park P, Copeland W, Yang L, Wang T, Botchan MR, Mohr IJ. 1994. Proc. Natl. Acad. Sci. USA 91:8700–4
  261. Collins KL, Kelly TJ. 1991. Mol. Cell. Biol. 11:2108–15
  262. Schneider C, Weibhart K, Guarino LA, Dornreiter I, Fanning E. 1994. Mol. Cell. Biol. 14:3176–85
  263. Stadlbauer F, Voitenleitner C, Bruckner A, Fanning E, Nasheuer H-P. 1996. Mol. Cell. Biol. 16:94–104
  264. Denis D, Bullock PA. 1993. Mol. Cell. Biol. 13:2882–90
  265. Bullock PA, Tevosian S, Jones C, Denis D. 1994. Mol. Cell. Biol. 14:5043–55
  266. Bullock PA, Denis D. 1995. Mol. Cell. Biol. 15:173–78
  267. Goulian M, Heard CJ. 1990. J. Biol. Chem. 265:13231–39
  268. Goulian M, Heard CJ, Grimm SL. 1990. J. Biol. Chem. 265:13221–30
  269. He ZG, Brinton BT, Greenblatt J, Hassell JA, Ingles CJ. 1993. Cell 73:1223–32
  270. Li R, Botchan MR. 1993. Cell 73:1207–21
  271. Eliasson R, Reichard P. 1978. J. Biol. Chem. 253:7469–75
  272. Shcherbakova PV, Pavlov YI. 1996. Genetics 142:717–26
  273. Navas TA, Zhou Z, Elledge SJ. 1995. Cell 80:29–39
  274. Navas TA, Sanchez Y, Elledge SJ. 1996. Genes Dev. 10:2632–43
  275. Elledge SJ. 1996. Science 274:1664–72
  276. Sugimoto K, Shimomura T, Hashimoto K, Araki H, Sugino A, Matsumoto K. 1996. Proc. Natl. Acad. Sci. USA 93:7048–52
  277. Araki H, Leem S-H, Phongdara A, Sugino A. 1995. Proc. Natl. Acad. Sci. USA 92:11791–95
  278. Saka Y, Yanagida M. 1993. Cell 74:383–93
  279. Saka Y, Fantes P, Sutani T, Mclnerny C, Creanor J, Yanagida M. 1994. EMBO J. 13:5319–29
  280. Saka Y, Esashi F, Matsusaka T, Mochida S, Yanagida M. 1997. Genes Dev. 11:3387–400
  281. Parker AE, Clyne RK, Carr AM, Kelly TJ. 1997. Mol. Cell. Biol. 17:2381–90
  282. Marini F, Pellicioli A, Paciotti V, Lucchini G, Plevani P. et al. 1997. EMBO J. 16:639–50
  283. D'Urso G, Grallert B, Nurse P. 1995. J. Cell Sci. 108:3109–18
  284. Francesconi S, De Recondo A-M, Baldacci G. 1995. Mol. Gen. Genet. 246:561–69
  285. Murakami H, Okayama H. 1995. Nature 374:817–19
  286. Sugimoto K, Ando S, Shimomura T, Matsumoto K. 1997. Mol. Cell. Biol. 17:5905–14
  287. Paulovich AG, Hartwell LH. 1995. Cell 82:841–47
  288. Waseem NH, Labib K, Nurse P, Lane DP. 1992. EMBO J. 11:5111–20
  289. Sherr CJ, Roberts JM. 1995. Genes Dev. 9:1149–63
  290. Sherr CJ. 1996. Science 274:1672–77
  291. Xiong Y, Zhang H, Beach D. 1993. Genes Dev. 7:1572–83
  292. Strausfeld UP, Howell M, Rempel R, Maller JL, Hunt T, Blow JJ. 1994. Curr. Biol. 4:876–83
  293. Jackson PK, Chevalier S, Philippe M, Kirschner MW. 1995. J. Cell Biol. 130:755–69
  294. Nichols AF, Sancar A. 1992. Nucleic Acids Res. 20:2441–46
  295. Shivji MKK, Kenny MK, Wood RD. 1992. Cell 69:367–74
  296. Li R, Waga S, Hannon GJ, Beach D, Stillman B. 1994. Nature 371:534–37
  297. Shivji MKK, Grey SJ, Strausfeld UP, Wood RD, Blow JJ. 1994. Curr. Biol. 4:1062–68
  298. Chen J, Jackson PK, Kirschner MW, Dutta A. 1995. Nature 374:386–88
  299. Goubin F, Ducommun B. 1995. Oncogene 10:2281–87
  300. Luo Y, Hurwitz J, Massague J. 1995. Nature 375:159–61
  301. Nakanishi M, Robetorye RS, Pereira-Smith OM, Smith JR. 1995. J. Biol. Chem. 270:17060–63
  302. Warbrick E, Lane DP, Glover DM, Cox LS. 1995. Curr. Biol. 5:275–82
  303. Chen I-T, Akamatsu M, Smith ML, Lung F-DT, Duba D. et al. 1996. Oncogene 12:595–607
  304. Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A. 1996. Mol. Cell. Biol. 16:4673–82
  305. Gibbs E, Kelman Z, Gulbis JM, O'Donnell M, Kuriyan J. et al. 1997. J. Biol. Chem. 272:2373–81
  306. Warbrick E, Lane DP, Glover DM, Cox LS. 1997. Oncogene 14:2313–21
  307. Funk JO, Waga S, Harry JB, Espling E, Stillman B, Galloway DA. 1997. Genes Dev. 11:2090–100
  308. Jones DL, Alani RM, Münger K. 1997. Genes Dev. 11:2101–11
  309. Greider CW, Collins K, Autexier C. 1996. See Ref. 314 619–38
  310. Carson MJ, Hartwell L. 1985. Cell 42:249–57
  311. Adams AK, Holm C. 1996. Mol. Cell. Biol. 16:4614–20
  312. Fan X, Price CM. 1997. Mol. Biol. Cell 8:2145–55
  313. Nugent CI, Hughes TR, Lue NF, Lundblad V. 1996. Science 274:249–52
  314. Stillman B. 1994. Cell 78:725–28
  315. De Pamphilis ML. ed 1996. DNA Replication in Eukaryotic Cells. Cold Spring Harbor, NY: Cold Spring Harbor Lab [Google Scholar]
/content/journals/10.1146/annurev.biochem.67.1.721
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THE DNA REPLICATION FORK IN EUKARYOTIC CELLS
Annual Review of Biochemistry 67, 721 (1998); https://doi.org/10.1146/annurev.biochem.67.1.721
/content/journals/10.1146/annurev.biochem.67.1.721
/content/journals/10.1146/annurev.biochem.67.1.721
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