1932

Abstract

A characteristic feature of cellular signal transduction pathways in eukaryotes is the separation of catalysis from target recognition. Several modular domains that recognize short peptide sequences and target signaling proteins to these sequences have been identified. The structural bases of the specificities of recognition by SH2, SH3, and PTB domains have been elucidated by X-ray crystallography and NMR, and these results are reviewed here. In addition, the mechanism of cooperative interactions between these domains is discussed.

Keyword(s): PDZPTBSH2SH3Src homologytyrosine kinase
Loading

Article metrics loading...

/content/journals/10.1146/annurev.biophys.26.1.259
1997-06-01
2024-03-28
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.biophys.26.1.259
Loading
/content/journals/10.1146/annurev.biophys.26.1.259
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error