1932

Abstract

Current models of signal transduction from the antigen receptors on B and T cells still resemble equations with several unknown elements. Data from recent knock-out experiments in cell lines and mice contradict the assumption that Src-family kinase and tyrosine kinases of the Syk/Zap-70 family are the transducer elements that set signaling from these receptors in motion. Using a functional definition of signaling elements, we discuss the current knowledge of signaling events from the BCR and suggest the existence of an as-yet-unknown BCR transducer complex.

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/content/journals/10.1146/annurev.immunol.15.1.453
1997-04-01
2024-03-29
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  • Article Type: Review Article
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