1932

Abstract

The promoter recognition specificity of RNA polymerase is modulated by replacement of the σ subunit in the first step and by interaction with transcription factors in the second step. The overall differentiated state of ∼2000 molecules of the RNA polymerase in a single cell can be estimated after measurement of both the intracellular concentrations and the RNA polymerase-binding affinities for all seven species of the σ subunit and 100–150 transcription factors. The anticipated impact from this line of systematic approach is that the prediction of the expression hierarchy of ∼4000 genes on the genome can be estimated.

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/content/journals/10.1146/annurev.micro.54.1.499
2000-10-01
2024-03-28
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  • Article Type: Review Article
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