1932

Abstract

The NMDA receptor (NMDAR) plays a central role in the function of excitatory synapses. Recent studies have provided interesting insights into several aspects of the trafficking of this receptor in neurons. The NMDAR is not a static resident of the synapse. Rather, the number and composition of synaptic NMDARs can be modulated by several factors. The interaction of PDZ proteins, generally thought to occur at the synapse, appears to occur early in the secretory pathway; this interaction may play a role in the assembly of the receptor complex and its exit from the endoplasmic reticulum. This review addresses recent advances in our understanding of NMDAR trafficking and its synaptic delivery and maintenance.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.pharmtox.43.100901.135803
2003-04-01
2024-03-29
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.pharmtox.43.100901.135803
Loading
/content/journals/10.1146/annurev.pharmtox.43.100901.135803
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error