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Annual Review of Genetics

Volume 38, 2004

Developmental Gene Amplification and Origin Regulation

Abstract

▪ Abstract 

Developmentally regulated gene amplification serves to increase the number of templates for transcription, yielding greatly increased protein and/or RNA product for gene(s) at the amplified loci. It is observed with genes that are very actively transcribed and during narrow windows of developmental time where copious amounts of those particular gene products are required. Amplification results from repeated firing of origins at a few genomic loci, while the rest of the genome either does not replicate, or replicates to a lesser extent. As such, amplification is a striking exception to the once-and-only-once rule of DNA replication and may be informative as to that mechanism. amplifies eggshell (chorion) genes in the follicle cells of the ovary to allow for rapid eggshell synthesis. amplifies multiple genes in larval salivary gland cells that encode proteins secreted in the saliva for the pupal case. Finally, amplifies its rRNA genes several thousand-fold in the creation of the transcriptionally active macronucleus. Due to the ease of molecular and genetic analysis with these systems, the study of origin regulation has advanced rapidly. Comparisons reveal an evolutionarily conserved -regulatory apparatus and a similar organization of sequence-specific -regulatory replicator and origin elements. The studies indicate a regulatory role for chromatin structure and transcriptionally active genes near the origins.

Keyword(s): Dbf4, DNA replication, ORC, replicator
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2004-12-15
2024-05-18
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Developmental Gene Amplification and Origin Regulation
Annual Review of Genetics 38, 273 (2004); https://doi.org/10.1146/annurev.genet.37.110801.143851
/content/journals/10.1146/annurev.genet.37.110801.143851
/content/journals/10.1146/annurev.genet.37.110801.143851
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