Spatiotemporal Basis of Innate and Adaptive Immunity in Secondary Lymphoid Tissue: Video 5

A video from the 2014 review by Hai Qi, Wolfgang Kastenmüller, and Ronald N. Germain, "Spatiotemporal Basis of Innate and Adaptive Immunity in Secondary Lymphoid Tissue," from the Annual Review of Cell and Developmental Biology.

Shown: CXCR6-GFP^bright (NKT) cells are highly motile

Popliteal LNs from CXCR6GFP/+ /CD11cYFP/+ mice were surgically exposed and analyzed by two-photon microscopy. Video shows dynamic behavior of CXCR6-GFP^bright cells close to the LN capsule near the interfollicular area.

Original publication: Kastenmüller W, Torabi-Parizi P, Subramanian N, Lammermann T, Germain RN. 2012. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell 150:1235–48