Spatiotemporal Basis of Innate and Adaptive Immunity in Secondary Lymphoid Tissue: Video 15
Abstract
A video from the 2014 review by Hai Qi, Wolfgang Kastenmüller, and Ronald N. Germain, "Spatiotemporal Basis of Innate and Adaptive Immunity in Secondary Lymphoid Tissue," from the Annual Review of Cell and Developmental Biology.
Shown: An isotropic ICOS-triggering field promotes coordinated actin dynamics, pseudopod extension, and persistent motility of T cells
After invitro activation and retroviral transduction with the LifeAct-mRubby F-actin reporter, T cells were imaged by TIRF microscopy on the anti-ICOS antibody-coated lipid bilayer.
Original publication: Xu H, Li X, Liu D, Li J, Zhang X, et al. 2013. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496:523–27
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